Background: Ex-preterm children and adolescents are at risk of developing late-onset
neurodevelopmental and behavioral disorders. The mechanisms by which this happens are …

Background Children born preterm, especially boys, are at increased risk of developing
attention deficit hyperactivity disorder (ADHD) and learning difficulties. We propose that …

Background Children that are born preterm are at an increased risk of developing cognitive
problems and behavioural disorders, such as attention deficit hyperactivity disorder (ADHD) …

Modulation of gamma-aminobutyric acid A (GABAA) receptor signalling by the neurosteroid
allopregnanolone has a major role in late gestation neurodevelopment. The objective of this …

Background: Preterm birth is a major cause of neurodevelopmental disorders.
Allopregnanolone, a key metabolite of progesterone, has neuroprotective and …

Elevated gestational concentrations of allopregnanolone are essential for the development
and neuroprotection of the foetal brain. Preterm birth deprives the foetus of these high levels …

Background A correct balance of activity of the GABA and glutamate systems is vital for
optimal neurodevelopment and general CNS function, and the dysregulation of this balance …

Progesterone and its neuroactive metabolite, allopregnanolone, are present in high
concentrations during pregnancy, but drop significantly following birth. Allopregnanolone …

Background: Maternal psychosocial stress during pregnancy is associated with adverse
neonatal outcomes. These outcomes result from changes in fetal brain development and …

Manipulation of the corticosteroid milieu by interfering with the mother–newborn relationship
has received much attention because of its potential bearing on psychopathology later in …