Excitatory amino acid neurotoxicity at the N-methyl-D-aspartate receptor in cultured neurons: role of the voltage-dependent magnesium block

JA Cox, PG Lysko, RC Henneberry - Brain research, 1989 - Elsevier
Results of the present report show that cerebellar neurons in primary culture are resistant to
glutamate concentrations as high as 5 mM in the presence of glucose and Mg 2+, but …

Extracellular acidic sulfur‐containing amino acids and γ‐glutamyl peptides in global ischemia: postischemic recovery of neuronal activity is paralleled by a tetrodotoxin …

P Andiné, O Orwar, I Jacobson… - Journal of …, 1991 - Wiley Online Library
An excessive activation of the excitatory amino acid system has been proposed as one
possible mediator of the ischemia‐induced delayed death of CA1 pyramidal cells in the …

Kainate toxicity in energy-compromised rat hippocampal slices: differences between oxygen and glucose deprivation

A Schurr, BM Rigor - Brain research, 1993 - Elsevier
The effects of kainate (KA) on the recovery of neuronal function in rat hippocampal slices
after hypoxia or glucose deprivation (GD) were investigated and compared to those of (R, S) …

Ion dependence and receptor mediation of glutamate toxicity in the immature rat hippocampal slice

A Lehmann, I Jacobson - European Journal of Neuroscience, 1990 - Wiley Online Library
Glutamate (glu) is a major excitatory transmitter and a toxin in the brain. In the present study,
the immature rat hippocampal slice was used to determine the morphology, topography …

Glutamate becomes neurotoxic via the N-methyl-D-aspartate receptor when intracellular energy levels are reduced

A Novelli, JA Reilly, PG Lysko, RC Henneberry - Brain research, 1988 - Elsevier
The N-methyl-d-aspartate (NMDA) subtype of glutamate receptor appears to play a pivotal
role in enabling glutamate to express its neurotoxic potential in a variety of neurological …

The Effect of Cyclohexyladenosine on the Penischemic Increases of Hippocampal Glutamate and Glycine in the Rabbit

SL Cantor, MH Zornow, LP Miller… - Journal of …, 1992 - Wiley Online Library
We investigated the ability of N6‐cyclohexyladenosine (CHA), a potent and selective agonist
of the adenosine A1 receptor, to attenuate elevations of levels of extracellular hippocampal …

Characteristics of hippocampal glycine release in cell-damaging conditions in the adult and developing mouse

P Saransaari, SS Oja - Neurochemical research, 2001 - Springer
The release of preloaded [3 H] glycine from hippocampal slices from 7-day-old and 3-month-
old (adult) mice was studied in different cell-damaging conditions, including hypoxia …

Bicarbonate-sensitive cysteine induced elevation of extra cellular aspartate and glutamate in rat hippocampus in vitro

AK Abbas, K Jardemark, A Lehmann, SG Weber… - Neurochemistry …, 1997 - Elsevier
The effect of different concentrations of cysteine (0.125, 0.25, 0.5 and 1mM) on the net efflux
of endogenous amino acids was studied by the incubation of rat hippocampal slices …

Acetoacetate protects hippocampal neurons against glutamate-mediated neuronal damage during glycolysis inhibition

L Massieu, ML Haces, T Montiel… - Neuroscience, 2003 - Elsevier
Glucose is the main substrate that fulfills energy brain demands. However, in some
circumstances, such as diabetes, starvation, during the suckling period and the ketogenic …

Calcium dependency of N-methyl-D-aspartate toxicity in slices from the immature rat hippocampus

K Ellren, A Lehmann - Neuroscience, 1989 - Elsevier
The literature on ionic requirements for excitotoxity is largely contradictory. Depending on
the experimental paradigms, it has been concluded that either Ca 2+ or Na+ and Cl …