Roles and regulation of neutral sphingomyelinase-2 in cellular and pathological processes
Our understanding of the functions of ceramide signaling has advanced tremendously over
the past decade. In this review, we focus on the roles and regulation of neutral …
the past decade. In this review, we focus on the roles and regulation of neutral …
Mammalian neutral sphingomyelinases: regulation and roles in cell signaling responses
Ceramide, a bioactive lipid, has been extensively studied and identified as an essential
bioactive molecule in mediating cellular signaling pathways. Sphingomyelinase …
bioactive molecule in mediating cellular signaling pathways. Sphingomyelinase …
[HTML][HTML] Neutral sphingomyelinases and nSMase2: bridging the gaps
There is strong evidence indicating a role for ceramide as a second messenger in processes
such as apoptosis, cell growth and differentiation, and cellular responses to stress …
such as apoptosis, cell growth and differentiation, and cellular responses to stress …
Structure of human nSMase2 reveals an interdomain allosteric activation mechanism for ceramide generation
MV Airola, P Shanbhogue… - Proceedings of the …, 2017 - National Acad Sciences
Neutral sphingomyelinase 2 (nSMase2, product of the SMPD3 gene) is a key enzyme for
ceramide generation that is involved in regulating cellular stress responses and exosome …
ceramide generation that is involved in regulating cellular stress responses and exosome …
Sphingolipid metabolism and neutral sphingomyelinases
Sphingolipids are an important class of lipid molecules that play fundamental roles in our
cells and body. Beyond a structural role, it is now clearly established that sphingolipids …
cells and body. Beyond a structural role, it is now clearly established that sphingolipids …
Cloned mammalian neutral sphingomyelinase: functions in sphingolipid signaling?
S Tomiuk, K Hofmann, M Nix… - Proceedings of the …, 1998 - National Acad Sciences
Sphingomyelin is an abundant constituent of the plasma membranes of mammalian cells.
Ceramide, its primary catabolic intermediate, is released by either acid sphingomyelinase or …
Ceramide, its primary catabolic intermediate, is released by either acid sphingomyelinase or …
Regulation of neutral sphingomyelinase-2 (nSMase2) by tumor necrosis factor-α involves protein kinase C-δ in lung epithelial cells
Neutral sphingomyelinases (N-SMases) are major candidates for stress-induced ceramide
production, but there is still limited knowledge of the regulatory mechanisms of the cloned N …
production, but there is still limited knowledge of the regulatory mechanisms of the cloned N …
Neutral sphingomyelinase 1 deficiency in the mouse causes no lipid storage disease
M Zumbansen, W Stoffel - Molecular and cellular biology, 2002 - Am Soc Microbiol
Sphingomyelin is a major lipid in the bilayer of subcellular membranes of eukaryotic cells.
Different sphingomyelinases catalyze the initial step in the catabolism of sphingomyelin, the …
Different sphingomyelinases catalyze the initial step in the catabolism of sphingomyelin, the …
Role for neutral sphingomyelinase-2 in tumor necrosis factor α-stimulated expression of vascular cell adhesion molecule-1 (VCAM) and intercellular adhesion …
Neutral sphingomyelinases (N-SMases) are major candidates for stress-induced ceramide
production. However, there is little information on the physiological regulation and roles of …
production. However, there is little information on the physiological regulation and roles of …
Inhibition of sphingomyelin hydrolysis: targeting the lipid mediator ceramide as a key regulator of cellular fate
RA Claus, MJ Dorer, AC Bunck… - Current medicinal …, 2009 - ingentaconnect.com
Ceramide, an intracellular lipid mediator, is generated by transient hydrolysis of
sphingomyelin in response to agonists inducing inflammation and apoptosis, ionizing …
sphingomyelin in response to agonists inducing inflammation and apoptosis, ionizing …