Our understanding of the functions of ceramide signaling has advanced tremendously over
the past decade. In this review, we focus on the roles and regulation of neutral …

Ceramide, a bioactive lipid, has been extensively studied and identified as an essential
bioactive molecule in mediating cellular signaling pathways. Sphingomyelinase …

There is strong evidence indicating a role for ceramide as a second messenger in processes
such as apoptosis, cell growth and differentiation, and cellular responses to stress …

Neutral sphingomyelinase 2 (nSMase2, product of the SMPD3 gene) is a key enzyme for
ceramide generation that is involved in regulating cellular stress responses and exosome …

Sphingolipids are an important class of lipid molecules that play fundamental roles in our
cells and body. Beyond a structural role, it is now clearly established that sphingolipids …

Sphingomyelin is an abundant constituent of the plasma membranes of mammalian cells.
Ceramide, its primary catabolic intermediate, is released by either acid sphingomyelinase or …

Neutral sphingomyelinases (N-SMases) are major candidates for stress-induced ceramide
production, but there is still limited knowledge of the regulatory mechanisms of the cloned N …

Sphingomyelin is a major lipid in the bilayer of subcellular membranes of eukaryotic cells.
Different sphingomyelinases catalyze the initial step in the catabolism of sphingomyelin, the …

Neutral sphingomyelinases (N-SMases) are major candidates for stress-induced ceramide
production. However, there is little information on the physiological regulation and roles of …

Ceramide, an intracellular lipid mediator, is generated by transient hydrolysis of
sphingomyelin in response to agonists inducing inflammation and apoptosis, ionizing …