Abstract The phosphatidylinositol 3‑kinase (PI3K)/protein kinase B (AKT) signaling pathway
is involved in the regulation of multiple cellular physiological processes by activating …

The human body consists of countless cells with the possibility of excessive and
uncontrolled proliferation under certain dysregulated circumstances that could cause …

Given that the PI3K/AKT pathway has manifested its compelling influence on multiple
cellular process, we further review the roles of hyperactivation of PI3K/AKT pathway in …

Abstract PI3K/AKT pathway is an important pathway in the carcinogenesis since it has
central impacts in the regulation of metabolic pathways, cell proliferation and survival, gene …

The phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway regulates multiple cellular
processes. An overactivation of the pathway is frequently present in human malignancies …

Abstract The phosphatidylinositol 3-kinase (PI3K)/Akt pathway plays a crucial role in various
cellular processes and is aberrantly activated in cancers, contributing to the occurrence and …

Background Ovarian cancer is one of the major causes of death in women worldwide.
Despite improvements in conventional treatment approaches, such as surgery and …

Phisiological activation of PI3K pathway is necessary for cells to regulate many different
physiological processes such as transcription, protein synthesis, metabolic responses and …

Abstract The phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway and c-Jun N-
terminal kinase (JNK) pathway are responsible for regulating a variety of cellular processes …

Phosphatidylinositol-3 kinases, PI3Ks, constitute a lipid kinase family characterized by their
ability to phosphorylate inositol ring 3′-OH group in inositol phospholipids to generate the …