Context: Multiple drug resistance is the major obstacle to conventional chemotherapy.
Silibinin, a nontoxic naturally occurring compound, has anticancer activity and can increase …

Significant emphasis is being placed on combination chemotherapy of cancer using
cytotoxic agents and naturally occurring chemopreventive agents, having different …

Background: Drug resistance and tumor metastasis are the main causes of treatment failure
and mortality in cancer patients. Silibinin, a naturally occurring flavanone, has been shown …

Background: Silibinin (SB), the main component of Silymarin (SM), is a natural substance
obtained from the seeds of the milk thistle. SM contains up to 70% of SB as two isoforms: A …

Purpose: Chemotherapies for breast cancer generally have strong cellular cytotoxicity and
severe side effects. Thus, significant emphasis has been placed on combinations of …

Small-cell lung carcinoma (SCLC) has a dismal prognosis in part because of multidrug
resistance (MDR). Silibinin is a flavonolignan extracted from milk thistle (Silybum marianum) …

Silibinin, a natural flavonoid, under phase I/II clinical trial in prostate cancer patients was
aimed to evaluate its chemotherapeutic potential in human breast cancer cell MCF7 and …

The acute and cumulative dose-related toxicity and drug resistance, mediated via nuclear
factor κB (NFκB), of anthracycline anticancer drugs pose a major problem in cancer …

Silibinin, with a strong antioxidant activity and a weak cytotoxic property, is considered a
candidate for cancer prevention. As there is no information on its effect on breast cancer …

Background The high systemic toxicity of chemotherapeutic agents limits their use to treat
clinical lung cancer. These limitations could be minimized/overcome by using non-toxic …