Major histocompatibility complex class I (MHCI) molecules modulate activity-dependent
refinement and plasticity. We found that MHCI also negatively regulates the density and …

Proper development of the central nervous system (CNS) requires the establishment of
appropriate connections between neurons. Recent work suggests that this process is …

Immune molecules have been discovered recently to play critical roles in the development,
function, and plasticity of the cerebral cortex. MHC class I (MHCI) molecules are expressed …

Class I major histocompatibility complex (class I MHC) molecules, known to be important for
immune responses to antigen, are expressed also by neurons that undergo activity …

Until recently, neurons in the healthy brain were considered immune-privileged because
they did not appear to express MHC class I (MHCI). However, MHCI mRNA was found to be …

For the nervous system to translate experience into memory and behavior, lasting structural
change at synapses must occur. This requirement is clearly evident during critical periods of …

Proteins of the major histocompatibility complex class I (MHCI) negatively regulate synapse
density in the developing vertebrate brain (;;), but the underlying mechanisms remain largely …

Research has long supported the view that the brain is immunologically privileged, in part
because normal, uninfected neurons were not thought to express major histocompatibility …

Although the brain has classically been considered “immune-privileged”, current research
suggests an extensive communication between the immune and nervous systems in both …

Major histocompatibility complex class I (MHCI) molecules negatively regulate cortical
connections and are implicated in neurodevelopmental disorders, including autism …