Caffeic acid and its derivatives as potential modulators of oncogenic molecular pathways: New hope in the fight against cancer
As a phenolic acid compound, caffeic acid (CA) can be isolated from different sources such
as tea, wine and coffee. Caffeic acid phenethyl ester (CAPE) is naturally occurring derivative …
as tea, wine and coffee. Caffeic acid phenethyl ester (CAPE) is naturally occurring derivative …
Chemical and pharmacological aspects of caffeic acid and its activity in hepatocarcinoma
KMM Espíndola, RG Ferreira, LEM Narvaez… - Frontiers in …, 2019 - frontiersin.org
Caffeic acid (CA) is a phenolic compound synthesized by all plant species and is present in
foods such as coffee, wine, tea, and popular medicines such as propolis. This phenolic acid …
foods such as coffee, wine, tea, and popular medicines such as propolis. This phenolic acid …
Caffeic acid derivatives inhibit the growth of colon cancer: involvement of the PI3-K/Akt and AMPK signaling pathways
EPI Chiang, SY Tsai, YH Kuo, MH Pai, HL Chiu… - PloS one, 2014 - journals.plos.org
Background The aberrant regulation of phosphatidylinositide 3-kinases (PI3-K)/Akt, AMP-
activated protein kinase (AMPK) and mammalian target of rapamycin (m-TOR) signaling …
activated protein kinase (AMPK) and mammalian target of rapamycin (m-TOR) signaling …
Growth inhibition by caffeic acid, one of the phenolic constituents of honey, in HCT 15 colon cancer cells
SK Jaganathan - The Scientific World Journal, 2012 - Wiley Online Library
Previous work from our laboratory showed that the mechanism of crude‐honey induced
apoptosis in colon cancer cells. Since phenolic constituents of honey were attributed to its …
apoptosis in colon cancer cells. Since phenolic constituents of honey were attributed to its …
Antiproliferative and apoptotic effects of caffeic acid on SK-Mel-28 human melanoma cancer cells
LP Pelinson, CE Assmann, TV Palma… - Molecular biology …, 2019 - Springer
Cutaneous melanoma (CM) is an extremely aggressive cancer presenting low survival and
high mortality. The vast majority of patients affected by this disease does not respond or …
high mortality. The vast majority of patients affected by this disease does not respond or …
Caffeic acid phenethyl ester (CAPE), derived from a honeybee product propolis, exhibits a diversity of anti-tumor effects in pre-clinical models of human breast cancer
Breast cancer (BC) patients use alternative and natural remedies more than patients with
other malignancies. Specifically, 63–83% use at least one type of alternative medicine and …
other malignancies. Specifically, 63–83% use at least one type of alternative medicine and …
Inhibitory effect of caffeic acid on cancer cell proliferation by oxidative mechanism in human HT-1080 fibrosarcoma cell line
N Rajendra Prasad, A Karthikeyan… - Molecular and cellular …, 2011 - Springer
Abstract Caffeic acid (3, 4-dihydroxy cinnamic acid)(CA) is naturally found in fruits,
vegetables, olive oil, and coffee. This study was undertaken to evaluate the anticancer effect …
vegetables, olive oil, and coffee. This study was undertaken to evaluate the anticancer effect …
Involvement of tumor suppressor protein p53 and p38 MAPK in caffeic acid phenethyl ester-induced apoptosis of C6 glioma cells
YJ Lee, HC Kuo, CY Chu, CJ Wang, WC Lin… - Biochemical …, 2003 - Elsevier
Caffeic acid phenethyl ester (CAPE), an active component of propolis, has many biological
and pharmacological activities including antioxidant, anti-inflammation, antiviral action, and …
and pharmacological activities including antioxidant, anti-inflammation, antiviral action, and …
[HTML][HTML] Synergistic anticancer activity of combined use of caffeic acid with paclitaxel enhances apoptosis of non-small-cell lung cancer H1299 cells in vivo and in vitro
J Min, H Shen, W Xi, Q Wang, L Yin, Y Zhang… - Cellular Physiology and …, 2018 - karger.com
Background/Aims: Caffeic acid (CA) is known to possess multiple biological activities
including anti-cancer activities. However, the molecular mechanisms underlying these …
including anti-cancer activities. However, the molecular mechanisms underlying these …
Caffeic acid phenethyl ester suppresses proliferation and survival of TW2. 6 human oral cancer cells via inhibition of Akt signaling
YY Kuo, HP Lin, C Huo, LC Su, J Yang… - International journal of …, 2013 - mdpi.com
Caffeic acid phenethyl ester (CAPE) is a bioactive component extracted from honeybee hive
propolis. Our observations indicated that CAPE treatment suppressed cell proliferation and …
propolis. Our observations indicated that CAPE treatment suppressed cell proliferation and …
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