Abstract Introduction and Aims North America is currently experiencing an epidemic of
opioid overdose deaths, driven by the proliferation of fentanyl in the street drug market …

Abstract Buprenorphine-naloxone (BUP-NX) is a lifesaving treatment for opioid use disorder.
The increasing use of illicitly manufactured fentanyl, however, has made initiating BUP-NX …

With the worst opioid overdose death crisis in the United States history, urgent new
approaches to assist people who use drugs onto medication for opioid use disorder are …

Background and Objectives Individuals exposed to fentanyl are at risk of precipitated
withdrawal using typical buprenorphine/naloxone induction procedures. Methods This case …

Background Buprenorphine–naloxone has a very high affinity for the mu-receptor and can
cause precipitated opioid withdrawal, typically more severe than withdrawal that occurs …

Objectives: Buprenorphine can precipitate withdrawal in opioid-dependent persons with
recent fentanyl use. However, the prevalence of this phenomenon is not clinically …

Objectives Buprenorphine treatment significantly reduces morbidity and mortality for people
with opioid use disorder. Fear of precipitated withdrawal remains a barrier to starting …

Abstract Background and Objectives Synthetic opioids, including fentanyl and fentanyl
analogs, account for over 70,000 annual overdose deaths in the United States, but there is …

Abstract Background and Objectives Fentanyl and other highly potent synthetic opioids are
the leading cause of opioid overdose deaths in the United States. Methods This study was …

Objectives: There has been a rapid increase in the presence of illicitly manufactured fentanyl
in the heroin drug supply. Buprenorphine is an effective treatment for heroin and prescription …