Under the auspices of the American Brain Injury Consortium and the Joint Section of
Neurotrauma and Critical Care of the American Association of Neurological Surgeons, the …

OBJECTIVE: Few randomized clinical trials (RCTs) in the field of traumatic brain injury (TBI)
have shown a significant treatment benefit. We critically reviewed the use of two types of …

Batteries of functional and cognitive measures have been proposed as alternatives to the
Extended Glasgow Outcome Scale (GOSE) as the primary outcome for traumatic brain injury …

Abstract A CONFERENCE WAS held in Houston, Texas, on October 8–9, 1991, to develop
recommendations for outcome measures for clinical trials in traumatic brain injury …

The aim of this study was to quantify the potential reduction in sample size that can be
achieved by adjustment for predictors of outcome in traumatic brain injury (TBI) trials. We …

Randomized controlled trials in traumatic brain injury (TBI) pose several complicated
methodological challenges related to the heterogeneity of the population. Several strategies …

Traumatic brain injury (TBI) is a global public health problem that affects the long-term
cognitive, physical, and psychological health of patients, while also having a major impact …

Traumatic brain injury (TBI) is a major health and socio-economic problem throughout the
world. Many randomized controlled trials (RCTs) have been performed to investigate the …

Substantial heterogeneity exists among patients who suffer from traumatic brain injury (TBI).
Strict enrollment criteria may diminish heterogeneity in randomized controlled trials (RCTs) …

Clinical trials in traumatic brain injury (TBI) pose complex methodological challenges,
largely related to the heterogeneity of the population. The International Mission on …