The nuclear pore complex (NPC) is a highly conserved channel in the nuclear envelope that
mediates mRNA export to the cytosol and bidirectional protein transport. Many chromosomal …

The gene gating hypothesis put forth by Blobel in 1985 was an alluring proposal outlining
functions for the nuclear pore complex (NPC) in transcription and nuclear architecture. Over …

Nuclear pore complexes (NPCs), the channels connecting the nucleus with the cytoplasm,
are the largest protein structures of the nuclear envelope. In addition to their role in …

The nuclear pore complex (NPC) is a massive nuclear envelope-embedded protein
complex, the canonical function of which is to mediate selective nucleocytoplasmic transport …

Within the nucleus, chromatin is functionally organized into distinct nuclear compartments.
The nuclear periphery, containing Nuclear Pore Complexes (NPCs), plays an important role …

Nuclear pore complexes are large multicomponent protein complexes that are embedded in
the nuclear envelope, where they mediate nucleocytoplasmic transport. In addition to …

Highlights•Nuclear pore complexes and nucleoporins have many transport-independent
functions.•Nuclear pore complexes play key roles in gene expression regulation.•In yeast …

Although the nuclear pore complex (NPC) is best known for its primary function as the key
regulator of molecular traffic between the cytoplasm and the nucleus, a growing body of …

Nuclear pore complexes (NPCs) are composed of several copies of∼ 30 different proteins
called nucleoporins (Nups). NPCs penetrate the nuclear envelope (NE) and regulate the …

In addition to their established roles in nucleocytoplasmic transport, the intimate association
of nuclear pore complexes (NPCs) with chromatin has long led to speculation that these …