Mutations on human presenilins 1 and 2 cause dominant early-onset familial Alzheimer's
disease (FAD). Presenilins are polytopic transmembrane proteins endoproteolytically …

Presenilin (PS1 and PS2) holoproteins are transiently incorporated into low molecular
weight (MW) complexes. During subsequent incorporation into a higher MW complex, they …

To gain insight into presenilin-1 (PS1) structural aspects, we explored the structure–function
relationship of its N-and C-terminal (NTF and CTF, respectively) complexes. We …

Mutations in the presenilin (PS) genes are linked to early onset familial Alzheimer's disease
(FAD). PS-1 proteins are proteolytically processed by an unknown protease to two stable …

A growing body of evidence indicates that presenilins could exist and be active as
oligomeric complexes. Using yeast two-hybrid and cell culture analysis, we provide …

Mutations in the highly homologous presenilin genes encoding presenilin-1 and presenilin-
2 (PS1 and PS2) are linked to early-onset Alzheimer's disease (AD). However, apart from a …

Humans inheriting missense mutations in thepresenilin (PS) 1 and-2 genes undergo
progressive cerebral deposition of the amyloid β-protein at an early age and develop a …

The enzyme γ-secretase is involved in the cleavage of several type I membrane proteins,
such as Notch 1 and amyloid precursor protein. Presenilin-1 (PS-1) is one of the critical …

Presenilin (PS1 and PS2) holoproteins are transiently incorporated into low molecular
weight (MW) complexes. During subsequent incorporation into a higher MW complex, they …

γ‐Secretase is an intramembrane cleaving protease involved in Alzheimer's disease. γ‐
Secretase occurs as a high molecular weight complex composed of presenilin (PS1/2) …