Energy homeostasis requires precise measurement of the quantity and quality of ingested
food. The vagus nerve innervates the gut and can detect diverse interoceptive cues, but the …

Neural inputs from internal organs are essential for normal autonomic function. The vagus
nerve is a key body-brain connection that monitors the digestive, cardiovascular, and …

Sensory neurons relay gut-derived signals to the brain, yet the molecular and functional
organization of distinct populations remains unclear. Here, we employed intersectional …

Food is a powerful natural reinforcer that guides feeding decisions. The vagus nerve
conveys internal sensory information from the gut to the brain about nutritional value; …

Given the crucial role of the gastrointestinal tract and associated organs in handling nutrient
assimilation and metabolism, it has long been known that its communication with the brain is …

Hunger, driven by negative energy balance, elicits the search for and consumption of food.
While this response is in part mediated by neurons in the hypothalamus, the role of specific …

The vagus nerve innervates many organs, and most, if not all, of its motor fibers are
cholinergic. However, no one knows its organizing principles—whether or not there are …

Food intake is tightly regulated by complex and coordinated gut-brain interactions. Nutrients
rapidly modulate activity in key populations of hypothalamic neurons that regulate food …

The brainstem dorsal vagal complex (DVC) is known to regulate energy balance and is the
target of appetite-suppressing hormones, such as glucagon-like peptide 1 (GLP-1). Here we …

A fundamental question of physiology is how gut-brain signaling stimulates appetite. While
many studies have emphasized the importance of vagal afferents to the brain in inducing …