Compounds that target D2-like dopamine receptors (DRs) are currently used as therapeutics
for several neuropsychiatric disorders including schizophrenia (antagonists) and …

The molecular alignments obtained from a previously reported pharmacophore model have
been employed in a three-dimensional quantitative structure− activity relationship (3D …

Dopamine receptor D2 (D2R) plays an important role in the human central nervous system
and is a focal target of antipsychotic agents. The D2HighR and D2LowR dimeric models …

“Evolution consists largely of molecular tinkering.”—Following the famous concept of the
molecular geneticist and medicine Nobel laureate François Jacob, in this review we …

Dopamine is an important neurotransmitter in the human brain and its altered concentrations
can lead to various neurological diseases. We studied the binding of novel compounds at …

The aim of this study was to use a combined structure and pharmacophore modeling
approach to extract information regarding dopamine D1 receptor agonism and D1/D2 …

We have previously reported on the ability of arylamide phenylpiperazines to bind
selectively to the D3 versus the D2 dopamine receptor subtype. For these studies, we used …

The dopamine D 2 receptor (D 2 R) is a common drug target for the treatment of a variety of
neurological disorders including schizophrenia. Structure based design of subtype selective …

Functionally selective ligands stabilize conformations of G protein-coupled receptors
(GPCRs) that induce a preference for signaling via a subset of the intracellular pathways …

A sequential docking methodology was applied to computationally predict starting points for
fragment linking using the human dopamine D3 receptor crystal structure and a human …