In light of the chronic problem of abuse of the controlled substance cocaine, we have
investigated novel approaches toward both understanding the activity of inhibitors of the …

The recent increase in the number of atomic-resolution structures of G protein-coupled
receptors (GPCRs) has contributed to a deeper understanding of ligand binding to several …

Diseases of the central nervous system are an alarming global problem showing an
increasing prevalence. Dopamine receptor D2 (D2R) has been shown to be involved in …

QSAR modeling was performed on 58 (S) N-[(1-ethyl-2-pyrrolidinyl) methyl]-6-methoxy
benzamides as dopamine (DA) D2 receptor antagonists to identify the structural …

Introduction: Dopamine is a neurotransmitter widely distributed in both the periphery and the
central nervous system (CNS). Its physiological effects are mediated by five closely related G …

A series of subtype selective dopamine D4 receptor ligands from the
hetroarylmethylphenylpiperazine class have been discovered that exhibit a remarkable …

Here we report a structure–activity relationship (SAR) study of analogues of 5/7-{[2-(4-aryl-
piperazin-1-yl)-ethyl]-propyl-amino}-5, 6, 7, 8-tetrahydro-naphthalen-2-ol. Our SAR is …

The dopamine 3 (D3) receptor is a promising therapeutic target for the treatment of nervous
system disorders, such as Parkinson's disease, and current research interests primarily …

The growing availability of novel structures for several G protein-coupled receptors (GPCRs)
has provided new opportunities for structure-based drug design of ligands against this …

The high affinity dopamine D4 receptor ligand APH199 and derivatives thereof exhibit bias
toward the Gi signaling pathway over β-arrestin recruitment compared to quinpirole. Based …