Human dopamine D4 receptor is a GPCR target in the treatment of neurological and
psychiatric conditions such as schizophrenia and Parkinson's disease. The X-ray structure of …

Conformational studies on a series of 1-phenyl-, 4-phenyl-, and l-benzyl-l, 2, 3, 4-
tetrahydroisoquinolines that possess an identical substituent pattern to the prototypical Dx …

Discovering dopamine D2-like receptor subtype-selective ligands has been a focus of
significant investigation. The D2R-selective antagonist 3-[4-(4-chlorophenyl)-4 …

A novel class of isochroman dopamine analogues, originally reported by Abbott
Laboratories, have> 100‐fold selectivity for D1‐like over D2‐like receptors. We synthesized …

The dopamine D2 and D3 receptors (D2R and D3R) are important targets for antipsychotics
and for the treatment of drug abuse. SB269652, a bitopic ligand that simultaneously binds …

Structure-based design methods commonly used in medicinal chemistry rely on a three-
dimensional representation of the receptor. However, few crystal structures are solved in …

The D 3 dopamine receptor represents an important target in drug addiction in that reducing
receptor activity may attenuate the self-administration of drugs and/or disrupt drug or cue …

We have recently reported G-protein coupled receptor (GPCR) model structures for the
active and inactive states of the human dopamine D2 receptor (D2R) using adrenergic …

Background: Despite the large amount of experimental data accumulated in the past decade
on G-protein-coupled receptor (GPCR) structure and function, understanding of the …

Background: Dopamine D2 and D3 receptors can form homo-and heterodimers and are
important targets in Schizophrenia and Parkinson's. Recently, many efforts have been made …