Our structural understanding of the superfamily of G-protein coupled receptors, a group of
targets of utmost pharmacological importance, has improved dramatically in the last few …

As an extension of a series of dopamine D3 receptor agonists involving FAUC 54, ex-chiral
pool synthesis, and biological evaluation of 3-substituted 7-aminotetrahydroindolizines was …

Dopamine D2 receptor homodimers might be of particular importance in the
pathophysiology of schizophrenia and, thus, serve as promising target proteins for the …

Dopamine (DA) is a critical neurotransmitter in the mammalian central nervous system
(CNS). The cerebral dopaminergic system is implicated in the pathophysiology of several …

Functional selectivity (or biased agonism) is a property exhibited by some G protein-coupled
receptor (GPCR) ligands, which results in the modulation of a subset of a receptor's …

Rigorously validated quantitative structure− activity relationship (QSAR) models have been
developed for 48 antagonists of the dopamine D1 receptor and applied to mining chemical …

Currently, there is mounting evidence that intermolecular receptor–receptor interactions may
result in altered receptor recognition, pharmacology and signaling. Heterobivalent ligands …

The D 2 dopamine receptor (D 2 DR) is an important target for the treatment of some central
nervous system disorders, such as Parkinson disease, schizophrenia and drug …

Neurleptic drugs, eg, aripiprazole, targeting the dopamine D2S and D3 receptors (D2SR
and D3R) in the central nervous system are widely used in the treatment of several psychotic …

Receptor based QSAR methods represent a computational marriage of structure activity
relationship analysis and receptor structure based design that is providing valuable …