Colorectal cancer (CRC) is one of the most common types of malignancy with high morbidity
and mortality rates worldwide. This biologically heterogeneous disease results in diverse …

Ovarian cancer is one of the leading causes of death from gynecological tumors in women.
Several lines of evidence suggest that estrogens may play an important role in ovarian …

Objective This study aimed at investigating whether a differential estrogen receptor beta (ER-
β) expression between the colonic subsites could correspond to a modification in …

Colorectal cancer (CRC) is the second cause of cancer-related death in both sexes
worldwide. As pre-menopausal women are less likely to develop CRC compared to age …

Estrogens, by binding to and activating two estrogen receptors (ERα and ERβ), are critically
involved in the development of the mammary gland and breast cancer. An isoform of ERβ …

Highlights•Functional outcomes of ERβ depend highly on cellular context and timing of
activation.•ERβ actions in breast cancer are dependent on ERα tumor status and …

Purpose Estrogen receptor β (ERβ) is abundantly expressed in colorectal tissue, but its role
in colorectal carcinogenesis remains elusive. Estrogen receptor coregulators, amplified in …

The protective role of estrogens in the colon carcinogenesis has been suggested for many
years and attributed mainly to estrogen receptor beta (ERβ). However, the direct effect of …

Estrogen hormones protect against colorectal cancer (CRC) and a preventative role of
estrogen receptor beta (ERβ) on CRC has been supported using full knockout animals …

Background Cutaneous melanoma is an aggressive malignancy; its incidence is increasing
worldwide and its prognosis remains poor. Clinical observations indicate that estrogen …