Cancer‐associated fibroblasts (CAF s) are considered the most abundant type of stromal
cells in pancreatic ductal adenocarcinoma (PDAC), playing a critical role in tumour …

Cancer stem cells (CSCs) play an important role in the clonogenic growth and metastasis of
pancreatic ductal adenocarcinoma (PDAC). A hallmark of PDAC is the desmoplastic …

Objective Cancer-associated fibroblasts (CAFs) play an important role in the progression of
pancreatic ductal adenocarcinoma (PDAC) by promoting tumor cell migration and drug …

Studies have shown that focal adhesion kinase (FAK) is overexpressed in several human
tumors and plays an important role in tumor progression. However, the role and underlying …

Despite substantial advances in the treatment of solid cancers, resistance to therapy
remains a major obstacle to prolonged progression-free survival. Pancreatic ductal …

Focal adhesion kinase (FAK) is a key regulator of growth factor receptor-and integrin-
mediated signals, governing fundamental processes in normal and cancer cells through its …

Objective We investigated how pancreatic cancer developed resistance to focal adhesion
kinase (FAK) inhibition over time. Design Pancreatic ductal adenocarcinoma (PDAC) …

It is twenty years since Focal Adhesion Kinase (FAK) was found to be overexpressed in
many types of human cancer. FAK plays an important role in adhesion, spreading, motility …

Focal adhesion kinase (FAK) is a cytoplasmic protein tyrosine kinase that is overexpressed
and activated in several advanced-stage solid cancers. FAK promotes tumour progression …

Abstract Background Pancreatic Cancer is one of the most lethal cancers, with less than 8%
of patients surviving 5 years following diagnosis. The last 40 years have seen only small …