Imbalance of circulating Tfr/Tfh ratio in patients with rheumatoid arthritis

X Wang, C Yang, F Xu, L Qi, J Wang, P Yang - Clinical and experimental …, 2019 - Springer
Follicular helper T (Tfh) cells and follicular regulatory T (Tfr) cells are critical for the
development and maintenance of germinal center and humoral immune responses …

[HTML][HTML] CD4+ CXCR5+ PD-1+ T follicular helper cells play a pivotal role in the development of rheumatoid arthritis

G Cao, S Chi, X Wang, J Sun… - Medical science monitor …, 2019 - ncbi.nlm.nih.gov
Background T follicular helper (Tfh) cells are a subgroup of activated CD4+ T cells in the
germinal centers of secondary lymphoid organs, they play critical roles in the development …

An imbalance between blood CD4+ CXCR5+ Foxp3+ Tfr cells and CD4+ CXCR5+ Tfh cells may contribute to the immunopathogenesis of rheumatoid arthritis

G Cao, P Wang, Z Cui, X Yue, S Chi, A Ma… - Molecular Immunology, 2020 - Elsevier
Abstract Background Follicular helper T (Tfh) cells are a subgroup of activated CD4+ T cells
which can assist the formation and maintenance of germinal centers. Follicular regulatory T …

Altered distribution of circulating T follicular helper-like cell subsets in rheumatoid arthritis patients

R Su, Y Wang, F Hu, B Li, Q Guo, X Zheng, Y Liu… - Frontiers in …, 2021 - frontiersin.org
Objective: Recent studies on follicular regulatory T (Tfr) and follicular helper T (Tfh) cells
suggest that they may participate in the pathogenesis of rheumatoid arthritis (RA). Here, we …

Circulating follicular helper–like T cells in systemic lupus erythematosus: association with disease activity

JY Choi, JH Ho, SG Pasoto, V Bunin… - Arthritis & …, 2015 - Wiley Online Library
Objective To assess circulating follicular helper T (Tfh)–like CD4+ T cells in patients with
systemic lupus erythematosus (SLE) and determine their relationship to disease activity …

The ratio of circulating follicular T helper cell to follicular T regulatory cell is correlated with disease activity in systemic lupus erythematosus

B Xu, S Wang, M Zhou, Y Huang, R Fu, C Guo… - Clinical …, 2017 - Elsevier
Follicular T regulatory (Tfr) cells inhibit follicular T helper (Tfh) cells mediated B cell
responses. Tfh cells are involved in the pathogenesis of systemic lupus erythematosus …

Increased frequency of circulating follicular helper T cells in patients with rheumatoid arthritis

J Ma, C Zhu, B Ma, J Tian, SE Baidoo… - Journal of …, 2012 - Wiley Online Library
Follicular helper T (Tfh) cells are recognized as a distinct CD4+ helper T‐cell subset, which
provides for B‐cell activation and production of specific antibody responses, and play a …

New insights into follicular helper T cell response and regulation in autoimmune pathogenesis

F Xiao, M Han, K Rui, X Ai, J Tian, W Zhang… - Cellular & Molecular …, 2021 - nature.com
Follicular helper T (Tfh) cells play a key role in driving B cell activation and differentiation
during germinal center reactions in immune responses and autoimmune development, and …

Increased circulating follicular Treg cells are associated with lower levels of autoantibodies in patients with rheumatoid arthritis in stable remission

C Liu, D Wang, S Lu, Q Xu, L Zhao, J Zhao… - Arthritis & …, 2018 - Wiley Online Library
Objective To examine the expression and changes in function of circulating CD 4+ CXCR 5+
FoxP3+ follicular Treg (Tfr) cells in patients with active rheumatoid arthritis (RA) and in …

Elevated circulating T cell subsets and cytokines expression in patients with rheumatoid arthritis

H Zhou, B Hu, Z Zhaopeng, J Liu, Q Zhong, Y Fan… - Clinical …, 2019 - Springer
Objective This study aimed to assess the role of different subsets of circulating follicular
helper T cells (Tfh), central memory (TCM), effector memory (TEM), Naïve T, chemokines …