Abstract Background: Aminoglycosides (AGs) and vancomycin (VM) are potentially
nephrotoxic antibiotics and their co-administration increases the incidence of nephrotoxicity …

The purpose of this study was to evaluate the effects of once daily (OD) or every 48 hours
(every-48-h) administration of amikacin (AMK) on renal function and ototoxicity in neonates …

Background Any event involving drug therapy that may interfere in a patient's desired clinical
outcome is called a drug related problem (DRP). DRP are very common in intensive therapy …

Neonates, especially preterms, are known to have low glomerular filtration rates (GFR). This
may result in elevated trough concentrations during multiple administration of …

OBJECTIVES: To study the current patterns of medication use, assess the extent of off-label
parenteral medication use, and evaluate evidence for efficacy and safety of parenteral …

Purpose: The aim of this work is to identify the most significant risk factors for hearing
impairment in high risk neonates hospitalized at our Neonatal Intensive Care Unit (NICU) …

Despite limited evidence on safety and efficacy of drug use in neonates, drugs are
extensively used in this age group. However, the availability of information on drug …

Off-label and unlicensed use of medicines is high in the paediatric population and
specifically high in neonatal/paediatric intensive settings with up to 90% of cases. This is …

AROCAS CASAN, Vicente et al. Off-label and unlicensed drug use in a Spanish Neonatal
Intensive Care Unit. Farm Hosp.[online]. 2017, vol. 41, n. 3, pp. 371-381. ISSN 2171-8695 …

Aims Neonates hospitalized in neonatal intensive care units (NICUs) commonly experience
adverse drug reactions (ADRs). Thus, we aimed to develop and validate a tool for predicting …