The purpose of this study was to evaluate the effects of once daily (OD) or every 48 hours
(every-48-h) administration of amikacin (AMK) on renal function and ototoxicity in neonates …

Objective: Because of the restraints on conducting studies on pharmaceutical use in sick
newborns, many drugs are used off-label in this population. Moreover, industrially …

Off-label and unlicensed use of medicines is high in the paediatric population and
specifically high in neonatal/paediatric intensive settings with up to 90% of cases. This is …

AROCAS CASAN, Vicente et al. Off-label and unlicensed drug use in a Spanish Neonatal
Intensive Care Unit. Farm Hosp.[online]. 2017, vol. 41, n. 3, pp. 371-381. ISSN 2171-8695 …

OBJECTIVE: To determine the prevalence of hearing loss and to analyze the results of
newborn hearing screening and audiological diagnosis in private health care systems …

Excipients affect the safety, efficacy and quality of medicines particularly in neonates who
are a highly vulnerable group of patients. At present there is a lack of data about the impact …

OBJECTIVES: The ototoxic action of systemic therapy with aminoglycoside antibiotics
leading to the loss of inner ear hair cells is well recognized. The mitochondria-mediated …

Aims Neonates hospitalized in neonatal intensive care units (NICUs) commonly experience
adverse drug reactions (ADRs). Thus, we aimed to develop and validate a tool for predicting …

Objectives This study aimed to assess the prevalence of Amikacin induced ototoxicity in
neonates in a tertiary care hospital and to elucidate the possible risk factors. Design: A …

What is known and objectives When considering acute care settings, such as the neonatal
intensive care unit (NICU), the inappropriate use of medicines poses a great risk to …