Background Many newborns may need to be hospitalized and receive drugs during the first
days of their lives. These drugs are fundamentally prescribed as off-label and unlicensed …

Background The information on neonatal exposure to excipients is limited. Previous studies
have focused on the excipients known to be toxic, but have not evaluated the general extent …

We evaluated 14 children on long-term peritoneal dialysis for ototoxicity associated with
aminoglycoside (AG) therapy. Baseline evaluation of all patients and 7 controls included …

Objective: this prospective study reports on the prevalence of hearing impairment in an at-
risk neonatal intensive care unit (NICU) population. Design: from 1990 to 1997, 942 …

Objectives Vancomycin is a glycopeptide antibiotic commonly used in neonatal intensive
care units (NICUs) to treat late onset sepsis. It is recommended that vancomycin trough …

Background Hospitalized neonates receive the highest number of drugs compared to all
other age groups, but consumption rates vary between studies depending on patient …

Background Drug related problems (DRPs) can interfere with the desired therapeutic
outcomes. Neonates are susceptible for DRP occurrence due to clinical heterogeneity …

Antibiotics are the leading cause of drug-induced kidney disease, and among them the
aminoglycosides (AMG) are the main nephrotoxic agents, bringing about kidney damage via …

Objective To characterize the association between gentamicin dosing, duration of treatment,
and ototoxicity in hospitalized infants. Study design This retrospective cohort study …

Background Multicenter neonatal clinical trials aim to provide evidence-based drug
evaluation, but recruiting neonates requires collaboration, standard procedures, and trained …