Increasing evidence indicates that interferon alpha (IFN-α) therapy is an effective treatment
option for a subgroup of patients with chronic hepatitis B virus (HBV) infection. It has been …

Hepatitis B virus is an enveloped DNA virus, that infects more than three hundred and sixty
million people worldwide and leads to severe chronic liver diseases. Interferon-alpha …

Adjuvant interferon‐α (IFN‐α) therapy is used to control certain types of cancer in clinics. For
hepatocellular carcinoma (HCC), IFN‐α therapy is effective in only a subgroup of patients; …

Interleukin 6 (IL‐6) is a pleiotropic cytokine with pivotal functions in the regulation of the
biological responses of several target cells, including hepatocytes. Previous studies have …

Interferon-α 5 (IFN-α 5) is the main IFN-α subtype expressed in the liver. Hepatitis C virus
(HCV) infection is associated with low IFN-α 5 mRNA levels, possibly reflecting an escape …

Interferon (IFN)-α is able to stimulate many cellular genes and inhibit the replication of
various viruses. However, it is unknown whether some IFN-stimulated genes (ISGs) …

Secretion of interferons (IFNs) from virus-infected cells is a hallmark of host antiviral
immunity and in fact, IFNs exert their antiviral activities through the induction of antiviral …

Therapeutic administration of type I IFN (IFN-I) is a common treatment option for individuals
suffering from hepatitis B virus (HBV) infection. IFN-I therapy, however, has a relatively low …

Abstract Background and Aim: Although interferon‐α (IFN‐α) is an effective treatment for
hepatitis B virus (HBV) infection, its precise mechanism of action has not been identified. In …

Interferon (IFN) helps cells fight viral infections by further inducing the expression of many
downstream IFN-stimulated genes (ISGs). Human interferon-inducible transmembrane …