The regional, cellular, and subcellular localization of phosphorylated p38 MAPK (pp38) was
examined by immunocytochemistry, immuofluorescent multiple labeling, and …

Alzheimer's disease (AD) is the most common cause of dementia in the elderly. AD is
characterized by progressive neuronal degeneration that is accompanied by the formation of …

The p38 mitogen‐activated protein kinase is a stress‐activated enzyme responsible for
transducing inflammatory signals and initiating apoptosis. In the Alzheimer's disease (AD) …

To understand the roles of p38 mitogen‐activated protein kinase (p38 MAPK) isoforms in
adult mouse brain, in vivo activities and detailed expression patterns of two p38 isoforms …

How senile plaques and neurofibrillary tangles are linked represents a major gap in our
understanding of the pathophysiology of Alzheimer's disease (AD). We have previously …

Activated (phosphorylated) mitogen-activated protein kinase p38 (MAPK-p38) and
interleukin-1 (IL-1) have both been implicated in the hyperphosphorylation of tau, a major …

Mitogen‐activated protein kinase (MAPK) p38 has been implicated in the pathogenesis of
Alzheimer's disease, but the upstream cascade leading to p38 activation has not been …

The temporal association between oxidative stress and the hallmark pathologies of
Alzheimer disease (AD) demonstrates that oxidative stress is among the earliest events in …

The abnormal hyperphosphorylation of tau in Alzheimer's disease (AD) has been proposed
to involve the extracellular-signal-regulated protein kinase (ERK) of the mitogen-activated …

Many studies have revealed a central role of p38 MAPK in neuronal plasticity and the
regulation of long-term changes in synaptic efficacy, such as long-term potentiation (LTP) …