Overview of current drug delivery methods across the blood–brain barrier for the treatment of primary brain tumors
R Haumann, JC Videira, GJL Kaspers… - CNS drugs, 2020 - Springer
Existing drug delivery methods have not led to a significant increase in survival for patients
with malignant primary brain tumors. While the combination of conventional therapies …
with malignant primary brain tumors. While the combination of conventional therapies …
Drug delivery across the blood-brain barrier for the treatment of pediatric brain tumors–An update
EA Power, JS Rechberger, S Gupta… - Advanced drug delivery …, 2022 - Elsevier
Even though the last decade has seen a surge in the identification of molecular targets and
targeted therapies in pediatric brain tumors, the blood brain barrier (BBB) remains a …
targeted therapies in pediatric brain tumors, the blood brain barrier (BBB) remains a …
Blood–brain barrier in brain tumors: biology and clinical relevance
F Mo, A Pellerino, R Soffietti, R Rudà - International journal of molecular …, 2021 - mdpi.com
The presence of barriers, such as the blood–brain barrier (BBB) and brain–tumor barrier
(BTB), limits the penetration of antineoplastic drugs into the brain, resulting in poor response …
(BTB), limits the penetration of antineoplastic drugs into the brain, resulting in poor response …
Novel delivery methods bypassing the blood-brain and blood-tumor barriers
BK Hendricks, AA Cohen-Gadol, JC Miller - Neurosurgical focus, 2015 - thejns.org
Glioblastoma (GBM) is the most common primary brain tumor and carries a grave prognosis.
Despite years of research investigating potentially new therapies for GBM, the median …
Despite years of research investigating potentially new therapies for GBM, the median …
Novel drug delivery strategies in neuro-oncology
DS Bidros, MA Vogelbaum - Neurotherapeutics, 2009 - Springer
Treatment of malignant gliomas represents one of the most formidable challenges in
oncology. Despite treatment with surgery, radiation therapy, and chemotherapy, the …
oncology. Despite treatment with surgery, radiation therapy, and chemotherapy, the …
Challenges in drug delivery to tumors of the central nervous system: an overview of pharmacological and surgical considerations
LP Serwer, CD James - Advanced drug delivery reviews, 2012 - Elsevier
The majority of newly diagnosed brain tumors are treated with surgery, radiation, and the
chemotherapeutic temozolomide. Development of additional therapeutics to improve …
chemotherapeutic temozolomide. Development of additional therapeutics to improve …
Drug delivery strategies to enhance the permeability of the blood–brain barrier for treatment of glioma
F Zhang, CL Xu, CM Liu - Drug Design, Development and Therapy, 2015 - Taylor & Francis
Gliomas are amongst the most insidious and destructive types of brain cancer and are
associated with a poor prognosis, frequent recurrences, and extremely high lethality despite …
associated with a poor prognosis, frequent recurrences, and extremely high lethality despite …
A comprehensive review in improving delivery of small-molecule chemotherapeutic agents overcoming the blood-brain/brain tumor barriers for glioblastoma treatment
Glioblastoma (GBM) is the most common and lethal primary brain tumor which is highly
resistant to conventional radiotherapy and chemotherapy, and cannot be effectively …
resistant to conventional radiotherapy and chemotherapy, and cannot be effectively …
Addressing BBB heterogeneity: A new paradigm for drug delivery to brain tumors
Effective treatments for brain tumors remain one of the most urgent and unmet needs in
modern oncology. This is due not only to the presence of the neurovascular unit/blood–brain …
modern oncology. This is due not only to the presence of the neurovascular unit/blood–brain …
Recent advances in brain tumor-targeted nano-drug delivery systems
Y Liu, W Lu - Expert opinion on drug delivery, 2012 - Taylor & Francis
Introduction: Brain tumors represent one of the most challenging and difficult areas in unmet
medical needs. Fortunately, the past decade has seen momentous developments in brain …
medical needs. Fortunately, the past decade has seen momentous developments in brain …
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