Abstract Purpose of Review Autoimmune-mediated destruction of insulin-producing β-cells
within the pancreas results in type 1 diabetes (T1D), which is not yet preventable or curable …

Summary Type 1 diabetes (T1D) develops when there are insufficient insulin-producing beta
cells to maintain glucose homeostasis. The prevailing view has been that T1D is caused by …

It has long been established that type 1 diabetes (T1D) is a T cell-mediated autoimmune
disease, with CD4+ and CD8+ T cells being largely responsible for the destruction of β cells …

Type 1 diabetes mellitus results from a T-cell mediated autoimmune destruction of the
pancreatic beta cells in genetically predisposed individuals. The knowledge of the …

While differentiating T-cell autoreactivity against pancreatic islets between type 1 diabetic
patients and nondiabetic control subjects as, over time, proven to be a difficult task, the …

A direct association of islet-autoreactive T cells with β cell destruction in human pancreatic
islets from type 1 diabetes (T1D) patients has never been demonstrated, and little is known …

Type 1 diabetes (T1D) represents 10 to 15% of all forms of diabetes. Its incidence shows a
consistent rise in all countries under survey. Evidence for autoimmunity in human T1D relies …

Type 1 diabetes (T1D) is a chronic autoimmune disease that causes severe loss of
pancreatic β cells. Autoreactive T cells are key mediators of β cell destruction. Studies of …

Type 1 diabetes (T1D) develops when insulin-secreting β-cells, found in the pancreatic islets
of Langerhans, are destroyed by infiltrating T cells. How human T cells recognize β-cell …

Type 1 diabetes (T1D) results from a complex interplay between genetic susceptibility and
environmental factors that have been implicated in the pathogenesis of disease both as …