Lateralized overgrowth (LO), or segmental overgrowth, is defined as an increase in growth
of tissue (bone, muscle, connective tissue, vasculature, etc.) in any region of the body. Some …

Simple Summary Congenital lateralized or segmental overgrowth (LO) disorders are
conditions characterized by excessive tissue growth of a body region often associated with a …

Simple Summary Lateralized overgrowth may be isolated or accompany syndromes.
Recently, international BWS consensus proposed that the patients with isolated lateralized …

Numerous multiple malformation syndromes associated with pathologic overgrowth have
been described and, for many, their molecular bases elucidated. This review describes the …

Background Somatic overgrowth conditions, including Proteus syndrome, Sturge–Weber
syndrome, and PIK3CA‐related overgrowth spectrum, are caused by post‐zygotic …

Abstract Background Overgrowth syndromes (eg, Beckwith–Wiedemann) are associated
with an increased risk of pediatric cancer, although there are few population‐based …

The congenital imprinting disorder, Beckwith‐Wiedemann syndrome (BWS) is associated
with variable clinical features including hemihypertrophy/lateralised overgrowth (LO) and …

Overgrowth syndromes, although rare, are diagnosed more frequently lately. Major
progress, such as the identification of genetic causes, has recently enhanced the delineation …

The overgrowth syndromes are important to diagnose, not just for accurate genetic
counseling, but also for knowledge surrounding cancer surveillance and prognosis. There …

We designate a novel term “isolated lateralized overgrowth”(ILO) for the findings previously
described as “isolated hemihypertrophy” and “isolated hemihyperplasia.” ILO is defined as …