In sickle cell disease (SCD), hemoglobin molecules polymerize intracellularly and lead to a
cascade of events resulting in decreased deformability and increased adhesion of red blood …

We present a microfluidic approach that allows simultaneous interrogation of RBC
properties in physiological flow conditions at a single cell level. With this method, we studied …

Non-adherence and deformability are the key intrinsic biomechanical features of the red
blood cell (RBC), which allow it to tightly squeeze and pass through even the narrowest of …

Sickle cell disease (SCD) is an inherited monogenic disease which is characterized by
distorted red blood cells (RBCs) that cause vaso-occlusion and vasculopathy. In the …

Sickle cell disease (SCD) is characterized by the abnormal deformation of red blood cells
(RBCs) in the deoxygenated condition, as their elongated shape leads to compromised …

In this work, we compared the dynamics of motion in a linear shear flow of individual red
blood cells (RBCs) from healthy and pathological donors (Sickle Cell Disease (SCD) or …

Sickle cell anemia (SCA) is an inherited blood disorder that causes painful crises due to
vaso-occlusion of small blood vessels. The primary cause of the clinical phenotype of SCA is …

Vaso-occlusive crisis, a common painful complication of sickle cell disease, is a complex
process triggered by intercellular adhesive interactions among blood cells and the …

Red blood cell (RBC) deformability is a valuable hemorheological biomarker that can be
used to assess the clinical status and response to therapy of individuals with sickle cell …

The pathology of sickle cell disease begins with the polymerization of intracellular
hemoglobin under low oxygen tension, which leads to increased blood effective viscosity …