Proteomics based systematic exploration of the peptidoglycan biosynthesis of Olsenella uli DSM 7084 towards pathogenesis

MS Akhtar, A Talat, T Bhardwaj, M Alsahag… - 2024 - researchsquare.com
The oral microbiota plays a pivotal role in either promoting health or exacerbating disease
progression. Within the diverse microbial community, Olsenella uli emerges as a concerning …

[HTML][HTML] Identification of a novel drug target in Porphyromonas gingivalis by a computational genome analysis approach

A Alqurashi, W Ahmad, Z Rahman, J Nawab… - Open …, 2024 - degruyter.com
This study applied a subtractive genomics approach to identify a potential drug target in the
Porphyromonas gingivalis strain (ATCC BAA-308/W83). The aim was to characterize the …

[HTML][HTML] Unveiling Therapeutic Potential: Targeting Fusobacterium nucleatum's Lipopolysaccharide Biosynthesis for Endodontic Infections—An In Silico Screening …

N Boreak, EA Alrajab, RA Nahari, LE Najmi… - International Journal of …, 2024 - mdpi.com
Complex microbial communities have been reported to be involved in endodontic infections.
The microorganisms invade the dental pulp leading to pulpitis and initiating pulp …

[HTML][HTML] Structure-Guided Computational Approaches to Unravel Druggable Proteomic Landscape of Mycobacterium leprae

SC Vedithi, S Malhotra… - Frontiers in Molecular …, 2021 - frontiersin.org
Leprosy, caused by Mycobacterium leprae (M. leprae), is treated with a multidrug regimen
comprising Dapsone, Rifampicin, and Clofazimine. These drugs exhibit bacteriostatic …

Exploring the diagnostic potential of extracellular metabolites produced by oral pathogen Porphyromonas gingivalis

S Zhang - 2023 - ses.library.usyd.edu.au
Periodontitis, one of the most prevalent chronic inflammatory diseases, is induced by
periodontal bacteria. Porphyromonas gingivalis, recognized as the" keystone pathogen," is …

Functional Proteomics Analysis of Norfloxacin-Resistant Edwardsiella tarda

J Wu, D Li, X Tan, X Chen, Y Liu… - Journal of Proteome …, 2023 - ACS Publications
Multidrug-resistant Edwardsiella tarda threatens both sustainable aquaculture and human
health, but the control measure is still lacking. In this study, we adopted functional …

Identification and qualitative characterization of new therapeutic targets in Stenotrophomonas maltophilia through in silico proteome exploration

RP Chakrabarty, ASMRU Alam, DK Shill… - Microbial …, 2020 - Elsevier
Stenotrophomonas maltophilia is an emerging opportunistic pathogen, and
immunocompromised patients are at a higher risk of getting infected with this nosocomial …

[图书][B] Using Chemical Tools to Identify and Inhibit Serine Hydrolases in Commensal Bacteria

LJ Keller - 2023 - search.proquest.com
With rising rates of antimicrobial resistance and an increasing understanding of how
commensal bacteria in the human microbiota affect a wide variety of diseases, it is of utmost …

Metabolites of the oral microbiome: important mediators of multikingdom interactions

A Barbour, O Elebyary, N Fine, M Oveisi… - FEMS Microbiology …, 2022 - academic.oup.com
The oral cavity hosts over 700 different microbial species that produce a rich reservoir of
bioactive metabolites critical to oral health maintenance. Over the last two decades, new …

[HTML][HTML] Subtractive proteomics approach to Unravel the druggable proteins of the emerging pathogen Waddlia chondrophila and drug repositioning on its MurB …

UF Chowdhury, A Al Saba, AS Sufi, AM Khan… - Heliyon, 2021 - cell.com
Waddlia chondrophila is an emerging pathogen that has been implicated in numerous
unpropitious pregnancy events in humans and ruminants. Taking into account its …