Nearly 50 naturally occurring carbapenem β‐lactam antibiotics, most produced by
Streptomyces, have been identified. The structural diversity of these compounds is limited to …

Approximately 50 naturally occurring carbapenem β‐lactam antibiotics are known. All but
one of these have been isolated from Streptomyces species and are disubstituted structural …

Three types of blocked mutants were isolated from Streptomyces griseus subsp. cryophilus,
which produces eight 5, 6-cis carbapenem antibiotics and penicillin N. The type I mutant was …

The generation of non-thienamycin-producing mutants with mutations in the thnL, thnN,
thnO, and thnI genes within the thn gene cluster from Streptomyces cattleya and their …

(Table 1). The above-described findings suggested that the four antibiotics were congeneric
compounds possessing a carbapenem skeleton and a pantothenyl group. The molecular …

In silico database searches allowed the identification in the S. flavogriseus ATCC 33331
genome of a carbapenem gene cluster highly related to the S. cattleya thienamycin one …

Carbapenem antibiotics are members of the β-lactam family of antibiotics, the most important
class of antibiotics currently in clinical use. They are active against many important Gram …

The pyrrole polyether antibiotic calcimycin (A23187) is a rare ionophore that is specific for
divalent cations. It is widely used as a biochemical and pharmacological tool because of its …

Abstract β-lactam ring formation in carbapenem and clavam biosynthesis proceeds through
an alternative mechanism to the biosynthetic pathway of classic β-lactam antibiotics. This …

Granaticin belongs to a class of aromatic polyketides, benzoisochromanequinone
antibiotics, among which actinorhodin is the most well-known member. The biosynthetic …