[HTML][HTML] Design, synthesis and biological evaluation of valepotriate derivatives as novel antitumor agents
Natural products remain the largest resources of lead compounds that can be used to
develop novel anticancer drug candidates. Based on deacetylisovaltratum, a natural product …
develop novel anticancer drug candidates. Based on deacetylisovaltratum, a natural product …
New Antiproliferative Triflavanone from Thymelaea hirsuta—Isolation, Structure Elucidation and Molecular Docking Studies
In this study isolates from Thymelaea hirsuta, a wild plant from the Sinai Peninsula of Egypt,
were identified and their selective cytotoxicity levels were evaluated. Phytochemical …
were identified and their selective cytotoxicity levels were evaluated. Phytochemical …
Iridoids from Valeriana jatamansi induce autophagy-associated cell death via the PDK1/Akt/mTOR pathway in HCT116 human colorectal carcinoma cells
YZ Tan, C Peng, CJ Hu, HX Li, WB Li, JL He, YZ Li… - Bioorganic …, 2019 - Elsevier
Abstract Chlorovaltrates UW (1–3), three previously undescribed iridoids, together with four
known analogues were isolated from the roots of Valeriana jatamansi. Their structures were …
known analogues were isolated from the roots of Valeriana jatamansi. Their structures were …
Structural simplification of evodiamine: Discovery of novel tetrahydro-β-carboline derivatives as potent antitumor agents
Z Ma, Y Huang, K Wan, F Zhu, C Sheng, S Chen… - Bioorganic & Medicinal …, 2021 - Elsevier
Natural products (NPs) have played a crucial role in the discovery and development of
antitumor drugs. However, the high structural complexity of NPs generally results in …
antitumor drugs. However, the high structural complexity of NPs generally results in …
Colorectal, prostate and pancreas human cancers targeted bioassay-guided isolations and characterization of chemical constituents from Tephrosia apollinea
Background: Cancer is characterized by uncontrolled cell division caused by dysregulation
of cell proliferation. Therefore, agents that impair cancer cell proliferation could have …
of cell proliferation. Therefore, agents that impair cancer cell proliferation could have …
Activity‐Guided Isolation of Cytotoxic Non‐Glycosidic Ester Iridoids from Valeriana alliariifolia Adams and Unravelling Their Cell Death Mechanisms
M Erdoğan, B Aru, UC Tayğun, C Şimşek… - Chemistry & …, 2022 - Wiley Online Library
The aim of this study was to isolate the cytotoxic compounds from V. alliariifolia via activity‐
guided isolation and to determine the mechanism of actions of the most potent ones. The …
guided isolation and to determine the mechanism of actions of the most potent ones. The …
Valtrate as a novel therapeutic agent exhibits potent anti-pancreatic cancer activity by inhibiting Stat3 signaling
L Chen, D Feng, Y Qian, X Cheng, H Song, Y Qian… - Phytomedicine, 2021 - Elsevier
Background Valtrate is a novel epoxy iridoid ester isolated from Chinese herbal medicine
Valeriana jatamansi Jones with anti-proliferative activity against various human cancer cell …
Valeriana jatamansi Jones with anti-proliferative activity against various human cancer cell …
Chamaejasmenin E from Stellera chamaejasme induces apoptosis of hepatocellular carcinoma cells by targeting c-Met in vitro and in vivo
XQ Yu, QL Yan, S Shen, ZY Cheng, XX Huang… - Bioorganic …, 2022 - Elsevier
Hepatocellular carcinoma (HCC), the most prevalent liver cancer, is considered one of the
most lethal malignancies with a dismal outcome. There is an urgent need to find novel …
most lethal malignancies with a dismal outcome. There is an urgent need to find novel …
Sesquiterpenoids isolated from the rhizome of Curcuma phaeocaulis Valeton: antitumor activity, in silico molecular docking and molecular dynamics study
X Zhong, X Yan, W Liu, Y Tian, R Song… - New Journal of …, 2023 - pubs.rsc.org
Three undescribed sesquiterpenoids, phaeocaulisguatriol (1) and phaeocaulistriol AB (19,
20), along with twenty known sesquiterpenoids were isolated from a chloroform-soluble …
20), along with twenty known sesquiterpenoids were isolated from a chloroform-soluble …
New tricks for an old natural product: discovery of highly potent evodiamine derivatives as novel antitumor agents by systemic structure–activity relationship analysis …
G Dong, S Wang, Z Miao, J Yao, Y Zhang… - Journal of medicinal …, 2012 - ACS Publications
Evodiamine is a quinazolinocarboline alkaloid isolated from the fruits of traditional Chinese
herb Evodiae fructus. Previously, we identified N13-substituted evodiamine derivatives as …
herb Evodiae fructus. Previously, we identified N13-substituted evodiamine derivatives as …