Catechol-O-methyltransferase (COMT) gene polymorphisms are associated with baseline disability but not long-term treatment outcome in patients with chronic low …
Purpose To examine the association between COMT and OPRM1 gene polymorphisms and
pain and disability at baseline and long-term follow-up in patients treated for chronic low …
pain and disability at baseline and long-term follow-up in patients treated for chronic low …
Genetic contribution of catechol-O-methyltransferase variants in treatment outcome of low back pain: a prospective genetic association study
Background Treatment outcome of low back pain (LBP) is associated with inter-individual
variations in pain relief and functional disability. Genetic variants of catechol-O …
variations in pain relief and functional disability. Genetic variants of catechol-O …
Association of catechol-O-methyltransferase genetic variants with outcome in patients undergoing surgical treatment for lumbar degenerative disc disease
F Dai, I Belfer, CE Schwartz, R Banco, JF Martha… - The Spine Journal, 2010 - Elsevier
BACKGROUND CONTEXT: Surgical treatment for lumbar degenerative disc disease (DDD)
has been associated with highly variable results in terms of postoperative pain relief and …
has been associated with highly variable results in terms of postoperative pain relief and …
Influence of variation in the catechol-O-methyltransferase gene on the clinical outcome after lumbar spine surgery for one-level symptomatic disc disease: a report on …
M Rut, A Machoy-Mokrzyńska, D Ręcławowicz… - Acta …, 2014 - Springer
Background This study was aimed at the evaluation of the relationship between genetic
polymorphisms of catechol-O-methyltransferase (COMT)(rs4680: A> G—Val158Met, rs6269 …
polymorphisms of catechol-O-methyltransferase (COMT)(rs4680: A> G—Val158Met, rs6269 …
The COMT rs 4680 M et allele contributes to long‐lasting low back pain, sciatica and disability after lumbar disc herniation
LM Jacobsen, EI Schistad, A Storesund… - … Journal of Pain, 2012 - Wiley Online Library
Background The COMT enzyme metabolizes catecholamines and thus modulates
adrenergic, noradrenergic and dopaminergic signaling. A functional polymorphism in the …
adrenergic, noradrenergic and dopaminergic signaling. A functional polymorphism in the …
The effect of catechol‐O‐methyltransferase polymorphisms on pain is modified by depressive symptoms
C Schwahn, HJ Grabe… - … Journal of Pain, 2012 - Wiley Online Library
Background Variations within the catechol‐O‐methyltransferase (COMT) gene have been
associated with pain severity in temporomandibular disorders (TMDs). Psychological factors …
associated with pain severity in temporomandibular disorders (TMDs). Psychological factors …
The relationship between disc degeneration, low back pain, and human pain genetics
KMC Cheung - The spine journal, 2010 - Elsevier
The relationship between disc degeneration, low back pain, and human pain genetics -
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No association between chronic musculoskeletal complaints and Val158Met polymorphism in the Catechol-O-methyltransferase gene. The HUNT study
K Hagen, E Pettersen, LJ Stovner, F Skorpen… - BMC Musculoskeletal …, 2006 - Springer
Abstract Background The Catechol-O-methyltransferase (COMT) gene contains a functional
polymorphism, Val158Met, that has been found to influence human pain perception. In one …
polymorphism, Val158Met, that has been found to influence human pain perception. In one …
Effect of catechol-O-methyltransferase polymorphism on response to propranolol therapy in chronic musculoskeletal pain: a randomized, double-blind, placebo …
IE Tchivileva, PF Lim, SB Smith, GD Slade… - Pharmacogenetics …, 2010 - journals.lww.com
Methods Forty Caucasian female participants meeting the Research Diagnostic Criteria for
TMD were genotyped for COMT polymorphisms and completed a randomized, double-blind …
TMD were genotyped for COMT polymorphisms and completed a randomized, double-blind …
Catechol-O-methyltransferase gene polymorphism and chronic human pain: a systematic review and meta-analysis
A Tammimäki, PT Männistö - Pharmacogenetics and genomics, 2012 - journals.lww.com
In human studies, low COMT (catechol-O-methyltransferase) activity has been associated
with increased sensitivity to acute clinical preoperative or postoperative pain. We explored …
with increased sensitivity to acute clinical preoperative or postoperative pain. We explored …