Co-expression of Cox-2 and EGFR in stage I human bronchial adenocarcinomas

K Araki, K Hashimoto, TD Ardyanto, M Osaki… - Lung Cancer, 2004 - Elsevier
Cyclooxygenase (Cox)-2 plays an important role in cell proliferation, carcinogenesis and
tumor growth, in part through the synthesis of prostaglandin E2 (PGE2) as well as through …

EGFR and COX-2 protein expression in non-small cell lung cancer and the correlation with clinical features

F Li, Y Liu, H Chen, D Liao, Y Shen, F Xu… - Journal of Experimental & …, 2011 - Springer
Background To evaluate the expression of EGFR and COX-2 and their correlation with
prognosis in NSCLC Methods The paraffin embedded tumor samples of 50 NSCLC patients …

Cyclooxygenase-2 protein levels are independent of epidermal growth factor receptor expression or activation in operable non-small cell lung cancer

CM Richardson, D Richardson, DEB Swinson… - Lung Cancer, 2005 - Elsevier
Both cyclooxygenase (COX)-2 and epidermal growth factor receptor (EGFR) are thought to
play important roles in the pathogenesis of non-small cell lung cancer (NSCLC). A number …

Prognostic significance of elevated cyclooxygenase 2 expression in primary, resected lung adenocarcinomas

H Achiwa, Y Yatabe, T Hida, T Kuroishi, K Kozaki… - Clinical Cancer …, 1999 - AACR
Recently, we demonstrated that elevated expression of cyclooxygenase 2 (COX-2) is
frequently seen in a specific type of lung cancer, ie, adenocarcinoma, and is possibly …

COX-2/EGFR expression and survival among women with adenocarcinoma of the lung

AL Van Dyke, ML Cote, GM Prysak, GB Claeys… - …, 2008 - academic.oup.com
Previous studies suggest that cyclooxygenase-2 (COX-2) expression may predict survival
among patients with non-small cell lung cancer. COX-2 may interact with epidermal growth …

Expression of COX-2 and its prognostic significance in non-small cell lung cancer

Q Zhang, HU Chengping, Y Hongzhong… - Zhongguo Fei Ai …, 2004 - search.proquest.com
目的 探讨非小细胞肺癌组织中 COX-2 的表达情况及其与患者临床病理生理特征和预后的关系.
方法 应用免疫组织化学 SP 法检测 52 例 NSCLC 组织中 COX-2 蛋白的表达情况. 结果 52 例 …

COX-2 expression during early lung squamous cell carcinoma oncogenesis

C Mascaux, B Martin, JM Verdebout… - European …, 2005 - Eur Respiratory Soc
Cyclooxygenase (COX)-2 is implicated in the oncogenesis of many cancers, and COX-2
inhibitors are effective in preventing the development of tumours, such as in colon cancer. Its …

Cox-2 in non-small cell lung cancer: a meta-analysis

H Jiang, J Wang, W Zhao - Clinica chimica acta, 2013 - Elsevier
BACKGROUND: We investigated the prognostic value of cyclooxygenase-2 (COX-2) for
survival of patients with non-small cell lung cancer (NSCLC). METHODS: We performed a …

[HTML][HTML] Prognostic value of COX-2 expression in patients with non-small cell lung cancer: a systematic review and meta-analysis

P Zhan, Q Qian, LK Yu - Journal of thoracic disease, 2013 - ncbi.nlm.nih.gov
Background Cyclooxygenase-2 (COX-2) has been implicated in tumorigenesis and
metastasis, and it presumably mediates the proliferation of endothelial cells and promotes …

Cyclooxygenase-2 (COX-2) negatively regulates expression of epidermal growth factor receptor and causes resistance to gefitinib in COX-2–overexpressing cancer …

YM Kim, SY Park, H Pyo - Molecular Cancer Research, 2009 - AACR
Abstract Overexpression of cyclooxygenase-2 (COX-2) and epidermal growth factor receptor
(EGFR) has been detected in many types of cancer. Although COX-2 and EGFR are closely …