BACKGROUND: Increasing numbers of tyrosine kinase inhibitors (TKIs) were studied and
approved for therapy of malignancies and other diseases. The aim of this study was to …

BACKGROUND: Tyrosine Kinase Inhibitors (TKIs) are a class of targeted drugs for the
treatment of malignant pathologies. The metabolic profile of these drugs can result in great …

Several studies have shown that therapeutic drug monitoring of tyrosine kinase inhibitors
(TKI) can improve their benefit in cancer. An analytical tool has been developed in order to …

A fast, sensitive, universal and accurate method for the determination of four different
tyrosine kinase inhibitors from biological material was developed using LC–MS/MS …

To support pharmacokinetic‐guided dosing in individual patients, a fast and accurate
method for simultaneous determination of anticancer tyrosine kinase inhibitors (TKIs) …

Background: A liquid chromatography/tandem mass spectrometry assay was developed to
facilitate therapeutic drug monitoring (TDM) for 10 anticancer compounds (dasatinib …

A sensitive, sophisticated and practical bioanalytical assay for the simultaneous
determination of six tyrosine kinase inhibitors (imatinib, sunitinib, nilotinib, dasatinib …

Background: A sensitive liquid chromatography coupled with tandem mass spectrometry
(MS/MS) method for the analysis in a small volume of plasma of 14 tyrosine kinase inhibitors …

The purpose of this study was to develop and validate a robust and sensitive LC–MS/MS
method for simultaneous determinations of various tyrosine kinase inhibitors (TKIs) in …

A reliable, high‐throughput and sensitive LC–MS/MS procedure was developed and
validated for the determination of five tyrosine kinase inhibitors in human plasma. Following …