Eosinophils: singularly destructive effector cells or purveyors of immunoregulation?

EA Jacobsen, AG Taranova, NA Lee, JJ Lee - Journal of Allergy and …, 2007 - Elsevier
Eosinophils are granulocytes typically associated with immune responses to a limited
number of specific insults, including helminth infection and exposure to various allergens …

Changing roles of eosinophils in health and disease

GT Furuta, FD Atkins, NA Lee, JJ Lee - Annals of allergy, asthma & …, 2014 - Elsevier
Objective To review and highlight the unappreciated roles of eosinophils suggested by
recent studies. Data Sources The literature, unpublished observations, and insights by the …

[HTML][HTML] The emerging roles of eosinophils: implications for the targeted treatment of eosinophilic-associated inflammatory conditions

C Lombardi, A Berti, M Cottini - Current research in immunology, 2022 - Elsevier
Eosinophils have multiple relevant biological functions, including the maintenance of
homeostasis, host defense against infectious agents, innate immunity activities, immune …

Eosinophils: friends or foes?

MJ Chusid - The Journal of Allergy and Clinical Immunology: In …, 2018 - Elsevier
The roles eosinophils are recognized to play in health and disease continue to evolve.
Formerly, eosinophils were believed to fill a primary role in host defense against helminths …

Immunoregulatory roles of eosinophils: a new look at a familiar cell

P Akuthota, HB Wang, LA Spencer… - Clinical & Experimental …, 2008 - Wiley Online Library
Eosinophils are usually considered as end‐stage degranulating effector cells of innate
immunity. However, accumulating evidence has revealed additional roles for eosinophils …

Contributions of eosinophils to human health and disease

AD Klion, SJ Ackerman… - Annual Review of …, 2020 - annualreviews.org
The human eosinophil has long been thought to favorably influence innate mucosal
immunity but at times has also been incriminated in disease pathophysiology. Research into …

Functions of tissue-resident eosinophils

PF Weller, LA Spencer - Nature Reviews Immunology, 2017 - nature.com
Eosinophils are a prominent cell type in particular host responses such as the response to
helminth infection and allergic disease. Their effector functions have been attributed to their …

Eosinophils: multifaceted biological properties and roles in health and disease

H Kita - Immunological reviews, 2011 - Wiley Online Library
Eosinophils are leukocytes resident in mucosal tissues. During T‐helper 2 (Th2)‐type
inflammation, eosinophils are recruited from bone marrow and blood to the sites of immune …

Eosinophils in health and disease: the LIAR hypothesis

JJ Lee, EA Jacobsen, MP McGarry… - Clinical & …, 2010 - Wiley Online Library
Discussions of eosinophils are often descriptions of end‐stage effector cells with destructive
capabilities mediated predominantly by released cytotoxic cationic granule proteins …

Eosinophils: changing perspectives in health and disease

HF Rosenberg, KD Dyer, PS Foster - Nature Reviews Immunology, 2013 - nature.com
Eosinophils have been traditionally perceived as terminally differentiated cytotoxic effector
cells. Recent studies have profoundly altered this simplistic view of eosinophils and their …