Perineuronal nets protect long-term memory by limiting activity-dependent inhibition from parvalbumin interneurons

W Shi, X Wei, X Wang, S Du, W Liu… - Proceedings of the …, 2019 - National Acad Sciences
Perineuronal nets (PNNs), a complex of extracellular matrix molecules that mostly surround
GABAergic neurons in various brain regions, play a critical role in synaptic plasticity. The …

Activation of perineuronal net-expressing excitatory neurons during associative memory encoding and retrieval

S Morikawa, Y Ikegaya, M Narita, H Tamura - Scientific reports, 2017 - nature.com
Abstract Perineuronal nets (PNNs), proteoglycan-rich extracellular matrix structures, are
thought to be expressed around inhibitory neurons and contribute to critical periods of brain …

Regulation of perineuronal nets in the adult cortex by the activity of the cortical network

G Devienne, S Picaud, I Cohen, J Piquet… - Journal of …, 2021 - Soc Neuroscience
Perineuronal net (PNN) accumulation around parvalbumin-expressing (PV) inhibitory
interneurons marks the closure of critical periods of high plasticity, whereas PNN removal …

Perineuronal nets affect parvalbumin expression in gaba ergic neurons of the mouse hippocampus

J Yamada, T Ohgomori, S Jinno - European Journal of …, 2015 - Wiley Online Library
Recent studies have suggested that the perineuronal net (PNN), a specialised extracellular
matrix structure, and parvalbumin (PV), an EF‐hand calcium‐binding protein, are involved in …

Perineuronal nets: plasticity, protection, and therapeutic potential

AC Reichelt, DJ Hare, TJ Bussey, LM Saksida - Trends in neurosciences, 2019 - cell.com
The relationship between neurons and perineuronal nets (PNNs) is attracting attention as a
central mechanism controlling brain plasticity. In the cortex, PNNs primarily surround …

Perineuronal nets control visual input via thalamic recruitment of cortical PV interneurons

G Faini, A Aguirre, S Landi, D Lamers, T Pizzorusso… - Elife, 2018 - elifesciences.org
In the neocortex, critical periods (CPs) of plasticity are closed following the accumulation of
perineuronal nets (PNNs) around parvalbumin (PV)-positive inhibitory interneurons …

Depletion of perineuronal nets enhances recognition memory and long-term depression in the perirhinal cortex

C Romberg, S Yang, R Melani… - Journal of …, 2013 - Soc Neuroscience
Perineuronal nets (PNNs) are extracellular matrix structures surrounding cortical neuronal
cell bodies and proximal dendrites and are involved in the control of brain plasticity and the …

Differential expression and cell-type specificity of perineuronal nets in hippocampus, medial entorhinal cortex, and visual cortex examined in the rat and mouse

KK Lensjø, AC Christensen, S Tennøe, M Fyhn… - eneuro, 2017 - eneuro.org
Perineuronal nets (PNNs) are specialized extracellular matrix (ECM) structures that
condense around the soma and proximal dendrites of subpopulations of neurons. Emerging …

Sensory experience-dependent formation of perineuronal nets and expression of Cat-315 immunoreactive components in the mouse somatosensory cortex

H Ueno, S Suemitsu, M Okamoto, Y Matsumoto… - Neuroscience, 2017 - Elsevier
Perineuronal nets (PNNs) are structures of extracellular matrix molecules surrounding the
cell bodies and proximal dendrites of certain neurons. While PNNs are present throughout …

Removal of perineuronal nets unlocks juvenile plasticity through network mechanisms of decreased inhibition and increased gamma activity

KK Lensjø, ME Lepperød, G Dick… - Journal of …, 2017 - Soc Neuroscience
Perineuronal nets (PNNs) are extracellular matrix structures mainly enwrapping
parvalbumin-expressing inhibitory neurons. The assembly of PNNs coincides with the end of …