Breakdown in cortical effective connectivity during midazolam-induced loss of consciousness

F Ferrarelli, M Massimini, S Sarasso… - Proceedings of the …, 2010 - National Acad Sciences
By employing transcranial magnetic stimulation (TMS) in combination with high-density
electroencephalography (EEG), we recently reported that cortical effective connectivity is …

Connectivity differences between consciousness and unconsciousness in non-rapid eye movement sleep: a TMS–EEG study

M Lee, B Baird, O Gosseries, JO Nieminen, M Boly… - Scientific reports, 2019 - nature.com
The neuronal connectivity patterns that differentiate consciousness from unconsciousness
remain unclear. Previous studies have demonstrated that effective connectivity, as assessed …

Cortical reactivity and effective connectivity during REM sleep in humans

M Massimini, F Ferrarelli, MJ Murphy… - Cognitive …, 2010 - Taylor & Francis
We recorded the electroencephalographic (EEG) responses evoked by transcranial
magnetic stimulation (TMS) during the first rapid eye movement (REM) sleep episode of the …

[HTML][HTML] Level of consciousness is dissociable from electroencephalographic measures of cortical connectivity, slow oscillations, and complexity

D Pal, D Li, JG Dean, MA Brito, T Liu… - Journal of …, 2020 - Soc Neuroscience
Leading neuroscientific theories posit a central role for the functional integration of cortical
areas in conscious states. Considerable evidence supporting this hypothesis is based on …

Hierarchical clustering of brain activity during human nonrapid eye movement sleep

M Boly, V Perlbarg, G Marrelec… - Proceedings of the …, 2012 - National Acad Sciences
Consciousness is reduced during nonrapid eye movement (NREM) sleep due to changes in
brain function that are still poorly understood. Here, we tested the hypothesis that impaired …

Decreased connectivity between the thalamus and the neocortex during human nonrapid eye movement sleep

D Picchioni, ML Pixa, M Fukunaga, WS Carr… - Sleep, 2014 - academic.oup.com
Abstract Study Objectives: To determine whether thalamocortical signaling between the
thalamus and the neocortex decreases from wakefulness to nonrapid eye movement …

Quantifying cortical EEG responses to TMS in (un) consciousness

S Sarasso, M Rosanova, AG Casali… - Clinical EEG and …, 2014 - journals.sagepub.com
We normally assess another individual's level of consciousness based on her or his ability to
interact with the surrounding environment and communicate. Usually, if we observe …

Consciousness and cortical responsiveness: a within-state study during non-rapid eye movement sleep

JO Nieminen, O Gosseries, M Massimini, E Saad… - Scientific Reports, 2016 - nature.com
When subjects become unconscious, there is a characteristic change in the way the cerebral
cortex responds to perturbations, as can be assessed using transcranial magnetic …

Altered global brain signal during physiologic, pharmacologic, and pathologic states of unconsciousness in humans and rats

S Tanabe, Z Huang, J Zhang, Y Chen, S Fogel… - …, 2020 - pubs.asahq.org
Background Consciousness is supported by integrated brain activity across widespread
functionally segregated networks. The functional magnetic resonance imaging–derived …

Decoupled temporal variability and signal synchronization of spontaneous brain activity in loss of consciousness: an fMRI study in anesthesia

Z Huang, J Zhang, J Wu, P Qin, X Wu, Z Wang, R Dai… - Neuroimage, 2016 - Elsevier
Two aspects of the low frequency fluctuations of spontaneous brain activity have been
proposed which reflect the complex and dynamic features of resting-state activity, namely …