Astaxanthin protects astrocytes against trauma-induced apoptosis through inhibition of NKCC1 expression via the NF-κB signaling pathway

M Zhang, Z Cui, H Cui, Y Wang, C Zhong - BMC neuroscience, 2017 - Springer
Background Astaxanthin (ATX) is a carotenoid pigment with pleiotropic pharmacological
properties that is seen as a possible drug for treating cerebral ischemic injury and …

Molecular mechanisms of astaxanthin as a potential neurotherapeutic agent

EI Bahbah, S Ghozy, MS Attia, A Negida, TB Emran… - Marine drugs, 2021 - mdpi.com
Neurological disorders are diseases of the central and peripheral nervous system that affect
millions of people, and the numbers are rising gradually. In the pathogenesis of …

Dose-dependent effects of astaxanthin on ischemia/reperfusion induced brain injury in mcao model rat

F Taheri, E Sattari, M Hormozi, H Ahmadvand… - Neurochemical …, 2022 - Springer
Excitotoxicity and oxidative stress are central to the pathology of the nervous system, and
inhibition of excitotoxicity induced by glutamate is one of the therapeutic goals determined …

Astaxanthin Suppresses H₂O₂-induced Apoptosis in H9c2 Cardiac Myoblast Cells

YJ Lim, SK Lee - 스트레스硏究, 2008 - dbpia.co.kr
Carotenoids (carotenes and xanthophylls) are antioxidant pigments found in vegetables,
fruits and crustaceans. Astaxanthin is one of the carotenoids (carotenoids and xanthophylls) …

Protective effect of astaxanthin on acute cerebral infarction in rats

Y Nai, H Liu, X Bi, H Gao, C Ren - Human & Experimental …, 2018 - journals.sagepub.com
The aim of the study was to investigate the effect of astaxanthin and its possible mechanisms
on acute cerebral infarction (ACI) in rat model. Male Sprague Dawley rats were randomly …

Astaxanthin ameliorates damage to the cerebral cortex, hippocampus and cerebellar cortex caused by methotrexate

R Aslankoc, O Ozmen, A Yalcın - Biotechnic & Histochemistry, 2022 - Taylor & Francis
We investigated the ameliorating effects of astaxanthin (AXA) on methotrexate (MTX)
induced damage to the cerebral cortex, hippocampus, cerebellar cortex and blood. We used …

Preventive treatment of astaxanthin provides neuroprotection through suppression of reactive oxygen species and activation of antioxidant defense pathway after …

L Pan, Y Zhou, X Li, Q Wan, L Yu - Brain research bulletin, 2017 - Elsevier
Astaxanthin, a natural antioxidant carotenoid, has been shown to reduce cerebral ischemic
injury in rodents. However, there have not been any studies specifically addressing whether …

Pretreatment of MQA, a caffeoylquinic acid derivative compound, protects against H2O2-induced oxidative stress in SH-SY5Y cells

X Tian, L Gao, L An, X Jiang, J Bai, J Huang… - Neurological …, 2016 - Taylor & Francis
Objectives: Compound MQA (1, 5-O-dicaffeoyl-3-O-[4-malic acid methyl ester]-quinic acid) is
a natural caffeoylquinic acid derivative isolated from Arctium lappa L. roots. This study aims …

Fucoxanthin provides neuroprotection in models of traumatic brain injury via the Nrf2-ARE and Nrf2-autophagy pathways

L Zhang, H Wang, Y Fan, Y Gao, X Li, Z Hu, K Ding… - Scientific reports, 2017 - nature.com
Fucoxanthin is abundant in seaweed and is considered as a powerful antioxidant. It has
been proposed to possess anti-cancer, anti-obesity and anti-diabetes effects. However, its …

Astragaloside IV reduces neuronal apoptosis and parthanatos in ischemic injury by preserving mitochondrial hexokinase-II

Y Li, Y Yang, Y Zhao, J Zhang, B Liu, S Jiao… - Free Radical Biology and …, 2019 - Elsevier
Cerebral ischemia induces neuronal cell death in different ways and mitochondrial
dysfunction is an important cause. Astragaloside IV (AIV) is a natural saponin abandent in …