This study explores the relationship between histologic variants of bone sarcomas and
previous therapy in patients in whom an unrelated malignant neoplasm had been …

Nine patients who had an osteosarcoma that had developed as a second malignant
neoplasm in a previously irradiated site were managed at a major center for the treatment of …

Osteosarcoma or chondrosarcoma developed as a second malignant neoplasm (SMN) in 40
of 188 individuals with SMN whose first neoplasm occurred in childhood. A genetic …

Currently, approximately 67% of children diagnosed with cancer can be expected to survive
more than 5 years. Among the most significant late effects of cancer therapy is the …

We estimated the risk of subsequent bone cancer among 9170 patients who had survived
two or more years after the diagnosis of a cancer in childhood. As compared with the …

PURPOSE: We analyzed the clinical features and outcome of patients with radiation-
associated osteosarcoma treated during the era of contemporary chemotherapy. PATIENTS …

PURPOSE AND METHODS Between January 1981 and June 1993, 137 children and
adolescents were each treated at the Institut Gustave Roussy for an initially nonmetastatic …

Bone sarcoma as a second malignancy is rare but highly fatal. The present knowledge
about radiation-absorbed organ dose–response is insufficient to predict the risks induced by …

BACKGROUND. The growing number of individuals surviving childhood cancer has
increased the awareness of adverse long‐term sequelae. One of the most worrisome …

We evaluated the rate of second malignancies in 1205 patients with osteosarcoma of the
extremity treated at our Institution with different protocols of adjuvant and neoadjuvant …