Endothelial nitric oxide synthase (eNOS) produces nitric oxide (NO) which, after diffusing
into vascular smooth muscle cells, activates guanylate cyclase leading to vasodilatation. A …

Among all physiologic functions of nitric oxide (NO) known so far, NO-dependent regulation
of vascular tone is one of the most important. Under physiological conditions vascular NO is …

Macro and microvascular diseases are the principal causes of morbidity and mortality in
patients with type I and II diabetes mellitus. Growing evidence implicates reactive nitrogen …

The 894G→ T polymorphism within exon 7 of the human endothelial nitric-oxide synthase
(eNOS) gene codes for glutamate or aspartate, respectively, at residue 298 and has been …

Incubation of endothelial cells in vitro with high concentrations of glucose activates protein
kinase C (PKC) and increases nitric oxide synthase (NOS III) gene expression as well as …

Endothelial nitric-oxide synthase (eNOS) is phosphorylated at Ser-1179 (bovine sequence)
by Akt after growth factor or shear stress stimulation of endothelial cells, resulting in …

Vasodilator actions of insulin are mediated by activation of endothelial nitric-oxide synthase
(eNOS) and subsequent production of NO. Phosphatidylinositol 3-kinase and Akt play …

Endothelial nitric-oxide synthase (eNOS) is an important regulator of endothelial function
and vascular tone in biological tissues. While endothelial dysfunction occurs following …

Protein kinase C (PKC) plays a key role in a variety of signal transduction processes. The
promoter region of the endothelial constitutive nitric oxide synthase (ecNOS) gene contains …

Endothelial dysfunction accompanies suboptimal glucose control in patients with diabetes
mellitus. A hallmark of endothelial dysfunction is a deficiency in production or bioavailability …