The Warburg effect in 2012 : Current Opinion in Oncology The Warburg effect in 2012 : Current
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Cancer is a major threat to human health. A considerable amount of research has focused
on elucidating the nature of cancer from its pathogenesis to treatment and prevention. Tumor …

Increased conversion of glucose to lactic acid associated with decreased mitochondrial
respiration is a unique feature of tumors first described by Otto Warburg in the 1920s. Recent …

Post-translational modification (PTM) is an important step of signal transduction that
transfers chemical groups such as phosphate, acetyl and glycosyl groups from one protein …

Warburg effect is a hallmark of cancer manifested by continuous prevalence of glycolysis
and dysregulation of oxidative metabolism. Glycolysis provides survival advantage to cancer …

In the 1920s, German biochemist Otto Warburg demonstrated that tumor cells produce
copious amounts of lactate despite the presence of ample oxygen—a phenomenon called …

The Warburg effect is prevalent in human cancer. Accordingly, most cancer cells display
highly elevated glycolysis without proportionally increasing pyruvate oxidation. The …

In the 1920s, Otto Warburg observed the phenomenon of altered glucose metabolism in
cancer cells. Although the initial hypothesis suggested that the alteration resulted from …

In contrast to normal differentiated cells, which rely primarily on mitochondrial oxidative
phosphorylation to generate the energy needed for cellular processes, most cancer cells …

A defining hallmark of tumor phenotypes is uncontrolled cell proliferation, while fermentative
glycolysis has long been considered as one of the major metabolic pathways that allows …