Abstract Phosphatidylinositol-3-kinase (PI3K) is a well-known regulator of cell division,
motility, and survival in most cell types. Recently, we characterized a novel protein that we …

PIK3R2 encodes a ubiquitous regulatory subunit (p85β) of PI3K, an enzyme that generates
3-polyphosphoinositides at the plasma membrane. PI3K activation triggers cell survival and …

Abstract Background Phosphoinositide-3-kinase, regulatory subunit 1 (PIK3R1) could
regulate cancer cell proliferation important for cancer cell proliferation; however, its role in …

Signaling initiated by Class Ia phosphatidylinositol-3-kinases (PI3Ks) is essential for cell
proliferation and survival. We discovered a novel protein we call PI3K interacting protein 1 …

There have long been indications of a role for PI3K (phosphatidylinositol 3-kinase) in cancer
pathogenesis. Experimental data document a requirement for deregulation of both …

Class I phosphoinositide 3‐kinase (PI3K) signaling is a major pathway in human cancer
development and progression. Among the four PI3K isoforms, PI3Kα and PI3Kβ are …

The assembly of signaling complexes at the plasma membrane is required for the initiation
and propagation of cellular signaling upon cell activation. The class I PI3K and the …

Abstract Phosphatidylinositol 3-kinases (PI3Ks) are crucial coordinators of intracellular
signalling in response to extracellular stimuli. Hyperactivation of PI3K signalling cascades is …

Abstract Phosphoinositide 3-kinase (PI3K) plays a critical role in tumorigenesis, and the
PI3K p85 regulatory subunit exerts both positive and negative effects on signaling …

Aberrations in the phosphoinositide 3-kinase (PI3K) signaling pathway play a key role in the
pathogenesis of numerous cancers by altering cellular growth, metabolism, proliferation …