Grafting embryonic raphe neurons reestablishes serotonergic regulation of sympathetic activity to improve cardiovascular function after spinal cord injury

S Hou, TM Saltos, E Mironets… - Journal of …, 2020 - Soc Neuroscience
Cardiovascular dysfunction often occurs after high-level spinal cord injury. Disrupting
supraspinal vasomotor pathways affects basal hemodynamics and contributes to the …

Partial restoration of cardiovascular function by embryonic neural stem cell grafts after complete spinal cord transection

S Hou, VJ Tom, L Graham, P Lu… - Journal of …, 2013 - Soc Neuroscience
High-level spinal cord injury can lead to cardiovascular dysfunction, including disordered
hemodynamics at rest and autonomic dysreflexia during noxious stimulation. To restore …

Relay strategies combined with axon regeneration: a promising approach to restore spinal cord injury

S Hou - Neural Regeneration Research, 2014 - journals.lww.com
1178 of these studies reported a relay mechanism to underlie the functional restoration.
Information from higher centers can be transmitted by grafted neuronal cells with different …

Autonomic Dysreflexia in Spinal Cord Injury: Mechanisms and Prospective Therapeutic Targets

CT Trueblood, A Singh, MA Cusimano… - The …, 2023 - journals.sagepub.com
High-level spinal cord injury (SCI) often results in cardiovascular dysfunction, especially the
development of autonomic dysreflexia. This disorder, characterized as an episode of …

Characterization of supraspinal vasomotor pathways and autonomic dysreflexia after spinal cord injury in F344 rats

S Hou, P Lu, A Blesch - Autonomic neuroscience, 2013 - Elsevier
Cardiovascular dysfunction usually occurs after high thoracic and cervical spinal cord injury
(SCI). The disruption of supraspinal vasomotor pathways (SVPs) results in the loss of …

Autonomic dysreflexia: a cardiovascular disorder following spinal cord injury

H Sharif, S Hou - Neural regeneration research, 2017 - journals.lww.com
Autonomic dysreflexia (AD) is a serious cardiovascular disorder in patients with spinal cord
injury (SCI). The primary underlying cause of AD is loss of supraspinal control over …

Olfactory ensheathing cells reduce duration of autonomic dysreflexia in rats with high spinal cord injury

T Kalinčík, EA Choi, F Féron, J Bianco… - Autonomic …, 2010 - Elsevier
Autonomic dysreflexia is a common complication in high spinal cord injury and can result in
serious consequences and death. Here we have examined the effect of acute …

Neuroprotection, plasticity manipulation, and regenerative strategies to improve cardiovascular function following spinal cord injury

JW Squair, CR West, AV Krassioukov - Journal of Neurotrauma, 2015 - liebertpub.com
Damage to the central nervous system, as in the case of spinal cord injury (SCI), results in
disrupted supraspinal sympathetic influence and subsequent cardiovascular control …

Development of cardiovascular dysfunction in a rat spinal cord crush model and responses to serotonergic interventions

CT Trueblood, IW Iredia, ES Collyer, VJ Tom… - Journal of …, 2019 - liebertpub.com
Selection of a proper spinal cord injury (SCI) rat model to study therapeutic effects of cell
transplantation is imperative for research in cardiovascular functional recovery, due to the …

Autonomic dysreflexia after spinal cord injury: central mechanisms and strategies for prevention

LC Weaver, DR Marsh, D Gris, A Brown… - Progress in brain …, 2006 - Elsevier
Spinal reflexes dominate cardiovascular control after spinal cord injury (SCI). These reflexes
are no longer restrained by descending control and they can be impacted by degenerative …