[引用][C] Amiodarone-lnduced Injury of Human Pulmonary Artery Endothelial Cells: Protection by a-Tocopherol1
DL KACHEL, TP MOVER, WJ MARTIN II - the journal of pharmacology, 1990
In vitro study on the pulmonary cytotoxicity of amiodarone
MT Alsamri, T Pramathan, AK Souid - Toxicology mechanisms and …, 2013 - Taylor & Francis
Context: Amiodarone (an iodinated benzofuran) is a Class III antiarrhythmic drug that
produces significant pulmonary disease. Proposed mechanisms of this cytotoxicity include …
produces significant pulmonary disease. Proposed mechanisms of this cytotoxicity include …
Combined treatment with l-carnitine and a pan-caspase inhibitor effectively reverses amiodarone-induced injury in cultured human lung epithelial cells
T Yano, Y Itoh, M Yamada, N Egashira, R Oishi - Apoptosis, 2008 - Springer
Amiodarone is an effective class III antiarrhythmic drug, however, the pulmonary toxicity is
one of the most life-threatening complications of its use. The present study was designed to …
one of the most life-threatening complications of its use. The present study was designed to …
Amiodarone protects cardiac myocytes against oxidative injury by its free radical scavenging action
T Ide, H Tsutsui, S Kinugawa, H Utsumi, A Takeshita - Circulation, 1999 - Am Heart Assoc
Background—Oxidative stress plays an important role in the pathophysiology of ischemic
heart disease and heart failure, and antioxidants might be beneficial in the treatment of …
heart disease and heart failure, and antioxidants might be beneficial in the treatment of …
Comparison of the in vivo pulmonary toxicity of amiodarone and des-oxo-amiodarone in the hamster
E Rafeiro, RG Leeder, JF Brien, GW Kabalka… - Toxicology and applied …, 1994 - Elsevier
Amiodarone (AM) is an effective antidysrhythmic agent, the use of which is limited because
of the drug′ s potential for causing life-threatening pulmonary fibrosis. Oxidative stress …
of the drug′ s potential for causing life-threatening pulmonary fibrosis. Oxidative stress …
Effects of vitamin E on cytotoxicity of amiodarone and N-desethylamiodarone in isolated hamster lung cells
MW Bolt, WJ Racz, JF Brien, TE Massey - Toxicology, 2001 - Elsevier
Amiodarone (AM) is a potent and efficacious antidysrhythmic agent that can cause
potentially life-threatening pulmonary fibrosis. Vitamin E has been demonstrated to …
potentially life-threatening pulmonary fibrosis. Vitamin E has been demonstrated to …
Cytotoxic interaction between amiodarone and desethylamiodarone in human peripheral lung epithelial cells
FC Roth, JE Mulder, JF Brien, T Takahashi… - Chemico-biological …, 2013 - Elsevier
The potent and efficacious anti-dysrhythmic agent amiodarone (AM) can cause potentially
life-threatening lung damage (amiodarone-induced pulmonary toxicity; AIPT), which is …
life-threatening lung damage (amiodarone-induced pulmonary toxicity; AIPT), which is …
[图书][B] Mechanisms of Amiodarone and N-desethylamiodarone Toxicity in Lung Cells
MW Bolt - 2002 - library-archives.canada.ca
Amiodarone (AM) is a potent antidysrhythmic agent that causes life-threatening pulmonary
fibrosis. Susceptibilities of different hamster lung cell types to AM-induced cytotoxicity were …
fibrosis. Susceptibilities of different hamster lung cell types to AM-induced cytotoxicity were …
[图书][B] Amiodarone-induced pulmonary toxicity in F344 rats
MD Taylor - 2001 - search.proquest.com
Amiodarone (AD) is gaining support as a first-line antiarrhythmic drug despite its potentially
fatal pulmonary toxicity involving inflammation and fibrosis. The goals of this study were to …
fatal pulmonary toxicity involving inflammation and fibrosis. The goals of this study were to …