Introdução: A maioria dos estudos experimentais sobre a toxicidade pulmonar induzida por
amiodarona tem sido realizada em ratos machos da linhagem Fischer-344. Objetivos …

Objective. Amiodarone, a class III antidysrhythmic agent, blocks Na+, Ca2+, and K+
channels as well as the β-adrenergic receptor. Despite increased use of amiodarone for …

The pacemaker current I f conducted by hyperpolarization‐activated cyclic nucleotide‐gated
(HCN) channels plays a critical role in the regulation of cardiac automaticity, with I f density …

Amiodarone (AD) is gaining support as a first-line antiarrhythmic drug despite its potentially
fatal pulmonary toxicity involving inflammation and fibrosis. The goals of this study were to …

Amiodarone, a class III antiarrhythmic drug, has been found to be effective in the
management of patients with life-threatening ventricular arrhythmias. The aim of this study …

Amiodarone, an iodinated benzofuran derivative, introduced in 1960's as an anti-anginal
agent, emerged as a potent anti-arrhythmic agent by 1970's and is currently one of the most …

Introdução: A maioria dos estudos experimentais sobre a toxicidade pulmonar induzida por
amiodarona tem sido realizada em ratos machos da linhagem Fischer-344. Objetivos …

Amiodarone‐(AM‐) induced pulmonary toxicity (AIPT) is still a matter of research and is
poorly understood. In attempting to resolve this issue, we treated Sprague‐Dawley rats with …

The efficacy of amiodarone is tempered by its toxicity, with 50% of long-term users
discontinuing the drug. The non-cardiac side effects of amiodarone may involve central and …

Introduction. The widely used antiarrhythmic amiodarone (AD) has been linked to many
health problems, including pulmonary toxicity. The objective of the study. In the present …