Neuropathic pain remains one of the most challenging of all neurological diseases and
presents a large unmet need for improved therapies. Many mechanistic details are still …

Over the past few decades, substantial advances have been made in neuropathic pain
clinical research. An updated definition and classification have been agreed. Validated …

Inflammation is the process by which an organism responds to tissue injury involving both
immune cell recruitment and mediator release. Diverse causes of neuropathic pain are …

The literature reveals that neuropathic pain is underdiagnosed and often undertreated or
treated with ineffective or untested modalities. Evolving definitions of neuropathic pain has …

Neuropathic pain represents a highly unmet medical need because most of the available
treatments have a modest efficacy or doselimiting side effects. Hence, novel therapeutic …

To provide a definition means to state the essential qualities of something. A definition is not
quite the same thing as a diagnosis, which is the art of identifying a disease from its signs …

Neuropathic pain is defined aspain initiated or caused by a primary lesion or dysfunction in
the nervous system'. 94 The spectrum of neuropathic pain covers a variety of disease states …

Clinical characteristics of neuropathic pain, ie pain after nervous system lesions, are burning
spontaneous pain, shooting pain attacks and evoked pains. Partly interacting …

IMPLICATIONS: A practical definition of neuropathic pain based on the distinction between
neuropathic and inflammatory pain mechanisms is suggested. Neuropathic pain is in this …

The transition from acute to chronic pain appears to occur in discrete pathophysiological and
histopathological steps. Stimuli initiating a nociceptive response vary, but receptors and …