Human whole genome genotype and transcriptome data for Alzheimer's and other neurodegenerative diseases
Previous genome-wide association studies (GWAS), conducted by our group and others,
have identified loci that harbor risk variants for neurodegenerative diseases, including …
have identified loci that harbor risk variants for neurodegenerative diseases, including …
Integrating human brain proteomes with genome-wide association data implicates new proteins in Alzheimer's disease pathogenesis
Genome-wide association studies (GWAS) have identified many risk loci for Alzheimer's
disease (AD),, but how these loci confer AD risk is unclear. Here, we aimed to identify loci …
disease (AD),, but how these loci confer AD risk is unclear. Here, we aimed to identify loci …
Genome-wide association study identifies four novel loci associated with Alzheimer's endophenotypes and disease modifiers
More than 20 genetic loci have been associated with risk for Alzheimer's disease (AD), but
reported genome-wide significant loci do not account for all the estimated heritability and …
reported genome-wide significant loci do not account for all the estimated heritability and …
Genetic risk for Alzheimer's disease is concentrated in specific macrophage and microglial transcriptional networks
Background Genome-wide association studies of Alzheimer's disease (AD) have identified a
number of significant risk loci, the majority of which lie in non-coding regions of the genome …
number of significant risk loci, the majority of which lie in non-coding regions of the genome …
Understanding Alzheimer disease at the interface between genetics and transcriptomics
J Verheijen, K Sleegers - Trends in Genetics, 2018 - cell.com
Over 25 genes are known to affect the risk of developing Alzheimer disease (AD), the most
common neurodegenerative dementia. However, mechanistic insights and improved …
common neurodegenerative dementia. However, mechanistic insights and improved …
A transcriptome-wide association study of Alzheimer's disease using prediction models of relevant tissues identifies novel candidate susceptibility genes
Background Genome-wide association studies (GWAS) have identified over 56 susceptibility
loci associated with Alzheimer's disease (AD), but the genes responsible for these …
loci associated with Alzheimer's disease (AD), but the genes responsible for these …
Shared genetic risk loci between Alzheimer's disease and related dementias, Parkinson's disease, and amyotrophic lateral sclerosis
Background Genome-wide association studies (GWAS) have indicated moderate genetic
overlap between Alzheimer's disease (AD) and related dementias (ADRD), Parkinson's …
overlap between Alzheimer's disease (AD) and related dementias (ADRD), Parkinson's …
Genome-wide association studies in Alzheimer disease
SC Waring, RN Rosenberg - Archives of neurology, 2008 - jamanetwork.com
The genetics of Alzheimer disease (AD) to date support an age-dependent dichotomous
model whereby earlier age of disease onset (< 60 years) is explained by 3 fully penetrant …
model whereby earlier age of disease onset (< 60 years) is explained by 3 fully penetrant …
Genes and pathways underlying regional and cell type changes in Alzheimer's disease
Abstract Background Transcriptional studies suggest Alzheimer's disease (AD) involves
dysfunction of many cellular pathways, including synaptic transmission, cytoskeletal …
dysfunction of many cellular pathways, including synaptic transmission, cytoskeletal …
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk
Alzheimer's disease (AD) is highly heritable and recent studies have identified over 20
disease-associated genomic loci. Yet these only explain a small proportion of the genetic …
disease-associated genomic loci. Yet these only explain a small proportion of the genetic …