Neurological impairment is crucial for tire rubber-derived contaminant 6PPDQ-induced acute toxicity to rainbow trout

XL Liao, ZF Chen, SP Ou, QY Liu, SH Lin, JM Zhou… - Science Bulletin, 2024 - Elsevier
Abstract N-(1, 3-dimethylbutyl)-N′-phenyl-p-phenylenediamine quinone (6PPDQ) has
attracted significant attention due to its highly acute lethality to sensitive salmonids …

Urine excretion, organ distribution, and placental transfer of 6PPD and 6PPD-quinone in mice and potential developmental toxicity through nuclear receptor pathways

HN Zhao, SP Thomas, MJ Zylka… - Environmental …, 2023 - ACS Publications
The rubber antioxidant 6PPD has gained significant attention due to its highly toxic
transformation product, 6PPD-quinone (6PPDQ). Despite their detection in urines of …

Concentration and leachability of N-(1, 3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) and its quinone transformation product (6PPD-Q) in road dust …

K Hiki, H Yamamoto - Environmental Pollution, 2022 - Elsevier
Abstract A recently identified chemical, 2-((4-Methylpentan-2-yl) amino)-5-(phenylamino)
cyclohexa-2, 5-diene-1, 4-dione (6PPD-quinone; 6PPD-Q), is a transformation product of an …

Establishing an In Vitro Model to Assess the Toxicity of 6PPD-Quinone and Other Tire Wear Transformation Products

JB Greer, EM Dalsky, RF Lane… - Environmental Science & …, 2023 - ACS Publications
The tire wear transformation product 6PPD-quinone (6PPDQ) has been implicated as the
causative factor for broad scale mortality events for coho salmon in the Pacific Northwest …

Acute Toxicity Testing of the Tire Rubber–Derived Chemical 6PPD‐quinone on Atlantic Salmon (Salmo salar) and Brown Trout (Salmo trutta)

A Foldvik, F Kryuchkov, R Sandodden… - Environmental …, 2022 - Wiley Online Library
Recent identification of 6PPD‐quinone as the chemical causing acute toxicity in coho
salmon has led to substantial concern regarding the toxicity of this contaminant for other …

A new toxicity mechanism of N-(1, 3-Dimethylbutyl)-N′-phenyl-p-phenylenediamine quinone: Formation of DNA adducts in mammalian cells and aqueous organisms

J Wu, G Cao, F Zhang, Z Cai - Science of The Total Environment, 2023 - Elsevier
Abstract N-(1, 3-dimethylbutyl)-N′-phenyl-p-phenylenediamine-quinone (6PPDQ), one of
the oxidation products of rubber antioxidant 6PPD, has been identified as a novel toxicant to …

Sunlight-Induced Transformation of Tire Rubber Antioxidant N-(1,3-Dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) to 6PPD-Quinone in Water

Y Zhou, L Yixi, Q Kong, J Peng, Y Pan… - … & Technology Letters, 2023 - ACS Publications
The huge consumption of the tire rubber antioxidant N-(1, 3-dimethylbutyl)-N′-phenyl-p-
phenylenediamine (6PPD) has resulted in pervasive contamination in aquatic environments …

Interspecies differences in 6PPD-quinone toxicity across seven fish species: Metabolite identification and semiquantification

D Montgomery, X Ji, J Cantin, D Philibert… - Environmental …, 2023 - ACS Publications
N-(1, 3-Dimethylbutyl)-N′-phenyl-p-phenylenediamine-quinone (6PPD-Q) is a recently
identified contaminant that originates from the oxidation of the tire antidegradant 6PPD …

Chemical characteristics, leaching, and stability of the ubiquitous tire rubber-derived toxicant 6PPD-quinone

X Hu, HN Zhao, Z Tian, KT Peter, MC Dodd… - … Science: Processes & …, 2023 - pubs.rsc.org
We here report chemical characteristics relevant to the fate and transport of the recently
discovered environmental toxicant 6PPD-quinone (2-((4-methylpentan-2-yl) amino)-5 …

Environmental fate of tire-rubber related pollutants 6PPD and 6PPD-Q: A Review

SC Ihenetu, Q Xu, ZH Khan, SSUIH Kazmi, J Ding… - Environmental …, 2024 - Elsevier
To enhance tire durability, the antioxidant N-(1, 3-dimethylbutyl)-N′-phenyl-p-
phenylenediamine (6PPD) is used in rubber, but it converts into the toxic 6PPD quinone …