Mind-body interrelationship in DNA methylation

M Szyf - Allergy and the Nervous System, 2012 - karger.com
DNA methylation is an enzymatic modification of the DNA molecule that confers unique
differential identities upon similar DNA sequences. DNA methylation plays a critical role in …

The effects of DNA methylation on human psychology

F Kader, M Ghai, L Maharaj - Behavioural brain research, 2018 - Elsevier
DNA methylation is a fundamental epigenetic modification in the human genome; pivotal in
development, genomic imprinting, X inactivation, chromosome stability, gene expression …

Social environment and DNA methylation: a mechanism for linking nurture and nature

M Szyf - Environmental Epigenomics in Health and Disease …, 2013 - Springer
During cellular differentiation cell type-specific DNA methylation patterns are formed which
are conserved during life maintaining cell type identity. Cellular differentiation is an innate …

DNA methylation, the early-life social environment and behavioral disorders

M Szyf - Journal of Neurodevelopmental Disorders, 2011 - Springer
One of the outstanding questions in behavioral disorders is untangling the complex
relationship between nurture and nature. Although epidemiological data provide evidence …

The early life social environment and DNA methylation: DNA methylation mediating the long-term impact of social environments early in life

M Szyf - Epigenetics, 2011 - Taylor & Francis
Although epidemiological data provides evidence that there is an interaction between
genetics (nature) and the social and physical environments (nurture) in human …

The genome-and system-wide response of DNA methylation to early life adversity and its implication on mental health

M Szyf - The Canadian Journal of Psychiatry, 2013 - journals.sagepub.com
Early life adversity is associated with long-tem impacts on behaviour and physical and
mental health. The mechanisms mediating the impact of early life environment on the …

DNA methylation: a transcriptional mechanism co-opted by the developed mammalian brain?

MA Mikaelsson, CA Miller - Epigenetics, 2011 - Taylor & Francis
Forming and maintaining behavioral memories is a complex process that involves, among
other requirements, transcriptional regulation and systems communication. Here we review …

The dynamic nature of DNA methylation: a role in response to social and seasonal variation

S Alvarado, RD Fernald, KB Storey… - … and comparative biology, 2014 - academic.oup.com
An organism's ability to adapt to its environment depends on its ability to regulate and
maintain tissue specific, temporal patterns of gene transcription in response to specific …

Examining peripheral DNA methylation in behavioral epigenetic and epigenetic psychiatry: opportunities and challenges

M Szyf - Epigenomics, 2014 - Taylor & Francis
Against this backdrop however, several studies have associated peripheral DNA
methylation changes in blood and saliva with social exposures, behavior, brain function and …

Neuronal activation and insight into the plasticity of DNA methylation

RJ Felling, JU Guo, H Song - Epigenomics, 2012 - Taylor & Francis
In a carefully choreographed sequence of events during vertebrate development, a single
cell divides and differentiates into hundreds of distinct cell types. What is most remarkable …