Antigen-specific T cells represent a potential therapeutic avenue for a variety of conditions,
but current approaches for generating such cells for therapeutic purposes are limited. In this …

Although adoptive transfer of cytotoxic T lymphocytes (CTL) offer a promising cancer
therapeutic direction, the generation of antigen-specific CTL from patients has faced difficulty …

Limited T cell availability and proliferative exhaustion present major barriers to successful T
cell-based immunotherapies and may potentially be overcome through the use of" …

Clinical successes demonstrated by chimeric antigen receptor T-cell immunotherapy have
facilitated further development of T-cell immunotherapy against wide variety of diseases …

Immunotherapies that augment antitumor T cells have had recent success for treating
patients with cancer. Here we examined whether tumor‐specific CD 4+ T cells enhance CD …

Intratumoral CD8+ T cells with stem cell–like properties: Implications for cancer
immunotherapy | Science Translational Medicine news careers commentary Journals …

Adoptive cell transfer (ACT) of genetically engineered T cells expressing cancer-specific T-
cell receptors (TCR) is a promising cancer treatment. Here, we investigate the in vivo …

Chimeric antigen receptor (CAR) T cell therapy has proven clinically beneficial against B cell
acute lymphoblastic leukemia and non-Hodgkin's lymphoma. However, suboptimal clinical …

Adoptive T‐cell therapy, where anti‐tumor T cells are first prepared in vitro, is attractive since
it facilitates the delivery of essential signals to selected subsets of anti‐tumor T cells without …

The genetic modification of CD8+ T cells using anti-tumor T-cell receptors (TCR) or chimeric
antigen receptors is a promising approach for the adoptive cell therapy of patients with …